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논문 기본 정보

자료유형
학술저널
저자정보
Basse Pierre (Department of Anesthesiology and Critical Care Medicine AP-HP Hôpital Lariboisière Paris France) Morisson Louis (Hôpital Maisonneuve-Rosemont CIUSSS de l’Est de l’Ile de Montréal Montréal Canada) Barthélémy Romain (Department of Anesthesiology and Critical Care Medicine AP-HP Hôpital Lariboisière Paris France) Julian Nathan (Department of Anesthesiology and Critical Care Medicine AP-HP Hôpital Lariboisière Paris France) Kindermans Manuel (Department of Anesthesiology and Critical Care Medicine AP-HP Hôpital Lariboisière Paris France) Collet Magalie (Department of Anesthesiology and Critical Care Medicine AP-HP Hôpital Lariboisière Paris France) Huot Benjamin (Department of Anesthesiology and Critical Care Medicine AP-HP Hôpital Lariboisière Paris France) Gayat Etienne (Department of Anesthesiology and Critical Care Medicine AP-HP Hôpital Lariboisière Paris France) Mebazaa Alexandre (Department of Anesthesiology and Critical Care Medicine AP-HP Hôpital Lariboisière Paris France) Chousterman Benjamin G. (Department of Anesthesiology and Critical Care Medicine AP-HP Hôpital Lariboisière Paris France)
저널정보
대한중환자의학회 Acute and Critical Care Acute and Critical Care 제38권 제2호
발행연도
2023.5
수록면
172 - 181 (10page)
DOI
10.4266/acc.2022.01494

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Background The role of positive pressure ventilation, central venous pressure (CVP) and inflammation on the occurrence of acute kidney injury (AKI) have been poorly described in mechanically ventilated patient secondary to coronavirus disease 2019 (COVID-19). Methods This was a monocenter retrospective cohort study of consecutive ventilated COVID-19 patients admitted in a French surgical intensive care unit between March 2020 and July 2020. Worsening renal function (WRF) was defined as development of a new AKI or a persistent AKI during the 5 days after mechanical ventilation initiation. We studied the association between WRF and ventilatory parameters including positive end-expiratory pressure (PEEP), CVP, and leukocytes count. Results Fifty-seven patients were included, 12 (21%) presented WRF. Daily PEEP, 5 days mean PEEP and daily CVP values were not associated with occurrence of WRF. 5 days mean CVP was higher in the WRF group compared to patients without WRF (median [IQR], 12 mm Hg [11-13] vs. 10 mm Hg [9–12]; P=0.03). Multivariate models with adjustment on leukocytes and Simplified Acute Physiology Score (SAPS) II confirmed the association between CVP value and risk of WRF (odd ratio, 1.97; 95% confidence interval, 1.12–4.33). Leukocytes count was also associated with occurrence of WRF in the WRF group (14 G/L [11–18]) and the no-WRF group (9 G/L [8–11]) (P=0.002). Conclusions In mechanically ventilated COVID-19 patients, PEEP levels did not appear to influence occurrence of WRF. High CVP levels and leukocytes count are associated with risk of WRF.

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