지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 512 - 518 (7page)
- DOI
- 10.3947/ic.2021.0060
이용수
초록· 키워드
오류제보하기
Background: The World Health Organization guidelines did not make a recommendation on use of remdesivir based on disease severity. Little is known regarding effectiveness of remdesivir in critically ill coronavirus disease 2019 (COVID-19) patients. This has led to a state of dilemma for doctors leaving them skeptical of whether they should continue to recommend the drug or not.
Materials and Methods: A systematic search adhering to preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines was conducted from inception until February 20, 2020. Electronic bibliographic databases (PubMed, Cochrane database, Scopus, Embase) were included. Using dichotomous data for select values, the unadjusted odds ratios (ORs) were calculated applying Mantel Haenszel (M-H) using random-effects model. The primary outcome of interest was all-cause mortality in ventilated and nonventilated patients.
Results: The Remdesivir arm was associated with similar rates of 28-day all-cause mortality (OR: 0.93, 95% confidence interval [CI]: 0.80 - 1.08; P = 0.33). Remdesivir was not found to be favorable for ventilated patients. Non ventilated COVID-19 patients showed a significant lower in-hospital mortality rate as compared with patients requiring mechanical ventilatory support (OR: 6.86, 95% CI: 5.39 - 268.74; P <0.0001).
Conclusion: Non-ventilated patients were associated with significant lower all-cause mortality rates. Prudent use of remdesivir is recommended in critically ill COVID-19 patients.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Eastman RT / 2020 / Remdesivir: a review of its discovery and development leading to emergency use authorization for treatment of COVID-19 / ACS Cent Sci 6:672~683
U. S. Food & Drug Administration (FDA) / Coronavirus (COVID-19) update: FDA issues emergency use authorization for potential COVID-19 treatment
WHO Solidarity Trial Consortium / 2021 / Repurposed antiviral drugs for Covid-19 - Interim WHO solidarity trial results / N Engl J Med 384:497~511
Moher D / 2009 / Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement / PLoS Med 6:e1000097
Beigel JH / 2020 / Remdesivir for the treatment of Covid-19 - final report / N Engl J Med 383:1813~1826
U. S. Food & Drug Administration (FDA) / Coronavirus (COVID-19) update: FDA issues emergency use authorization for potential COVID-19 treatment
WHO Solidarity Trial Consortium / 2021 / Repurposed antiviral drugs for Covid-19 - Interim WHO solidarity trial results / N Engl J Med 384:497~511
Moher D / 2009 / Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement / PLoS Med 6:e1000097
Beigel JH / 2020 / Remdesivir for the treatment of Covid-19 - final report / N Engl J Med 383:1813~1826
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