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논문 기본 정보

자료유형
학술저널
저자정보
de Souza Gabriela Leite (Department of Endodontics School of Dentistry Federal University of Uberlândia Uberlândia Brazil.) Freitas Gabrielle Alves Nunes (School of Dentistry Federal University of Uberlândia Uberlândia Brazil.) Ribeiro Maria Tereza Hordones (Department of Operative Dentistry and Dental Materials School of Dentistry Federal University of Uberlândia Uberlândia Brazil.) Lemus Nelly Xiomara Alvarado (Department of Endodontics School of Dentistry Federal University of Uberlândia Uberlândia Brazil.) Soares Carlos José (Department of Operative Dentistry and Dental Materials School of Dentistry Federal University of Uberlândia Uberlândia Brazil.) Moura Camilla Christian Gomes (Department of Endodontics School of Dentistry Federal University of Uberlândia Uberlândia Brazil.)
저널정보
대한치과보존학회 Restorative Dentistry and Endodontics Restorative Dentistry and Endodontics 제48권 제2호
발행연도
2023.5
수록면
1 - 15 (15page)
DOI
10.5395/rde.2023.48.e21

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Objectives This study evaluated the effects of Biodentine (BD), Bio-C Repair (BCR), and mineral trioxide aggregate (MTA) plug on the fracture resistance of simulated immature teeth with replacement root resorption (RRR) and in vitro-induced osteoclastogenesis. Materials and Methods Sixty bovine incisors simulating immature teeth and RRR were divided into 5 groups: BD and BCR groups, with samples completely filled with the respective materials; MTA group, which utilized a 3-mm apical MTA plug; RRR group, which received no root canal filling; and normal periodontal ligament (PL) group, which had no RRR and no root canal filling. All the teeth underwent cycling loading, and compression strength testing was performed using a universal testing machine. RAW 264.7 macrophages were treated with 1:16 extracts of BD, BCR, and MTA containing receptor activator of nuclear factor-kappa B ligand (RANKL) for 5 days. RANKL-induced osteoclast differentiation was assessed by staining with tartrate-resistant acid phosphatase. The fracture load and osteoclast number were analyzed using 1-way ANOVA and Tukey’s test (α = 0.05). Results No significant difference in fracture resistance was observed among the groups (p > 0.05). All materials similarly inhibited osteoclastogenesis (p > 0.05), except for BCR, which led to a lower percentage of osteoclasts than did MTA (p < 0.0001). Conclusions The treatment options for non-vital immature teeth with RRR did not strengthen the teeth and promoted a similar resistance to fractures in all cases. BD, MTA, and BCR showed inhibitory effects on osteoclast differentiation, with BCR yielding improved results compared to the other materials.

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