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논문 기본 정보

자료유형
학술저널
저자정보
Özdemir Pınar Gökmirza (Department of Pediatric Allergy and Immunology Trakya University School of Medicine Edirne Turkey.Department of Allergy Clinical Research Center for Allergy and Rheumatology National Hospital Organiza) Sato Sakura (Department of Allergy Clinical Research Center for Allergy and Rheumatology National Hospital Organization Sagamihara National Hospital Kanagawa Japan.) Yanagida Noriyuki (Department of Allergy Clinical Research Center for Allergy and Rheumatology National Hospital Organization Sagamihara National Hospital Kanagawa Japan.) Ebisawa Motohiro (Department of Allergy Clinical Research Center for Allergy and Rheumatology National Hospital Organization Sagamihara National Hospital Kanagawa Japan.)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.15 No.2
발행연도
2023.3
수록면
125 - 144 (20page)
DOI
10.4168/aair.2023.15.2.125

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Food allergy (FA) has become more prevalent and problematic in the last 2 decades, and it poses important individual, social, and economic burdens. Besides treating reactions induced by accidental exposure and periodic evaluation for acquiring natural tolerance, the primary management approach is still allergen avoidance as a global standard. However, an active therapeutic approach that can raise the reaction threshold or accelerate tolerance is needed. This review aimed to provide an overview and the latest evidence of oral immunotherapy (OIT), which has recently been used in the active treatment of FA. FA immunotherapy, particularly OIT, is gaining considerable interest, and substantial effort has been made to integrate this active treatment into clinical practice. Consequently, growing evidence has been obtained regarding the efficacy and safety of OIT, particularly for allergens such as peanuts, eggs, and milk. However, several issues need to be addressed regarding the availability, safety, and long-term effects of this intervention. In this review, we summarize currently available information regarding tolerance-inducing immune mechanisms of OIT, data on efficacy and safety, gaps in current evidence, and ongoing research to develop new therapeutic molecules in order to enhance safety.

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