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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.2
- 수록면
- 84 - 89 (6page)
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The implications of nutrient starvation due to aging on the degenerationof the retinal pigment epithelium (RPE) is yet to befully explored. We examined the involvement of AMPK activationin mitochondrial homeostasis and its relationship withthe maintenance of a healthy mitochondrial population andepithelial characteristics of RPE cells under nutrient starvation.
Nutrient starvation induced mitochondrial senescence, whichled to the accumulation of reactive oxygen species (ROS) inRPE cells. As nutrient starvation persisted, RPE cells underwentpathological epithelial-mesenchymal transition (EMT) via theupregulation of TWIST1, a transcription regulator which is activatedby ROS-induced NF-κB signaling. Enhanced activationof AMPK with metformin decelerated mitochondrial senescenceand EMT progression through mitochondrial biogenesis, primedby activation of PGC1-α. Thus, by facilitating mitochondrial biogenesis,AMPK protects RPE cells from the loss of epithelialintegrity due to the accumulation of ROS in senescent mitochondriaunder nutrient starvation.
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