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논문 기본 정보

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학술저널
저자정보
Fahmi Shibli (Department of Medicine Division of Gastroenterology and Hepatology Esophageal and Swallowing Center MetroHealth Medical Center Case Western Reserve University Cleveland OH USA) Ofer Z Fass (Department of Medicine Division of Gastroenterology and Hepatology Stanford University Stanford CA USA) Oscar Matsubara Teramoto (Department of Gastroenterology ABC Medical Center PMG Santa Fe Contadero Cuajimalpa de Morelos Mexico) José M Remes-Troche (Deapartment of Digestive Physiology and Motility Laboratory Medical Biological Research Institute University of Veracruz Veracruz Mexico) Vikram Rangan (Department of Medicine Division of Gastroenterology and Hepatology Digestive Disease Center Beth Israel Deaconess Medical Center Harvard University Boston MA USA) Michael Kurin (Department of Medicine Division of Gastroenterology and Hepatology University Hospitals Cleveland Medical Center Case Western Reserve University Cleveland OH USA) Ronnie Fass (Department of Medicine Division of Gastroenterology and Hepatology Esophageal and Swallowing Center MetroHealth Medical Center Case Western Reserve University Cleveland OH USA)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.29 No.1
발행연도
2023.1
수록면
31 - 37 (7page)
DOI
10.5056/jnm21255

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Background/AimsPresently, there is paucity of information about clinical predictors, especially esophageal motor abnormalities, for long segment Barrett’s esophagus (LSBE) as compared with short segment Barrett’s esophagus (SSBE). The aims of this study are to compare the frequency of esophageal function abnormalities between patients with LSBE and those with SSBE and to determine their clinical predictors. MethodsThis was a multicenter cohort study that included all patients with a diagnosis of BE who underwent high-resolution esophageal manometry. Motility disorders were categorized as hypercontractile disorders or hypocontractile disorders and their frequency was compared between patients with LSBE and those with SSBE. Multivariable logistic regression modeling was used to calculate the odds of being diagnosed with LSBE relative to SSBE for demographics, comorbidities, medication use, endoscopic findings, and the type of motility disorders. ResultsA total of 148 patients with BE were identified, of which 89 (60.1%) had SSBE and 59 (39.9%) LSBE. Patients with LSBE had a significantly larger hiatal hernia and higher likelihood of erosive esophagitis than patients with SSBE (P = 0.002). Patients with LSBE had a significantly lower mean LES resting pressure, distal contractile integral, distal latency, and significantly higher failed swallows and hypocontractile motility disorders than those with SSBE (P < 0.05). Hiatal hernia and hypocontractile motility disorder increased the odds of LSBE by 38.0% and 242.0%, as opposed to SSBE. ConclusionsThe presence of a hypocontractile motility disorder increased the risk for LSBE. Furthermore, the risk for LSBE was directly associated with the length of the hiatal hernia.

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