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자료유형
학술저널
저자정보
Sakineh Amani (Department of Basic Sciences School of Veterinary Medicine Shiraz University Shiraz Iran) Noorbakhsh Mohammad Foad (Department of Basic Sciences School of Veterinary Medicine Shiraz University Shiraz Iran) Ahmadi Nasrollah (Department of Pathobiology School of Veterinary Medicine Shiraz University Shiraz Iran) Saeed Nazifi (Department of Clinical Sciences School of Veterinary Medicine Shiraz University Shiraz Iran) Behdokht Barzan (Department of Basic Sciences School of Veterinary Medicine Shiraz University Shiraz Iran)
저널정보
대한약침학회 Journal of Pharmacopuncture Journal of Pharmacopuncture 제26권 제2호
발행연도
2023.6
수록면
184 - 191 (8page)
DOI
10.3831/KPI.2023.26.2.184

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Objectives: Several studies have reported that methotrexate is an anti-cancer and immunosuppressive drug leading to lung injury. Therefore, the present study aimed to investigate the protective effects of silymarin, citral, and thymoquinone on methotrexate-induced pulmonary toxicity. Methods: Forty-eight rats were divided into six groups, including healthy, Methotrexate, and drug carrier control groups and silymarin, citral, and thymoquinone treatment groups. At the end of the experiment, the studied rats were anesthetized and sacrificed by CO 2 . Lung tissue samples were isolated to measure the antioxidant activity and histopathological evaluation. Results: In the thymoquinone treatment group, the concentration of total antioxidant capacity and Malondialdehyde increased and decreased significantly, respectively, compared to the methotrexate group. The histopathological evaluation of the lung of the methotrexate group showed hemorrhage and congestion, the nodule-like accumulation of mononuclear inflammatory lymphocytes around the blood vessel, a small number of neutrophils around the blood vessel, and the inflammatory cells around the small vessels. However, no significant pathological alterations were observed in the treatment groups, especially the thymoquinone treatment group. Conclusion: Thymoquinone has the greatest protective effect on methotrexate-induced lung injury, probably due to its antioxidant effect.

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