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논문 기본 정보

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학술저널
저자정보
Shi Yong (State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Nanjing Drum Tower Hospital The Afliated Hospital of) Zhang Xiaoxuan (State Key Laboratory of Bioelectronics School of Biological Sci ence and Medical Engineering Southeast University) Liu Rui (Department of Rheumatology and Immunology Institute of Translational Medicine The Afliated Drum Tower Hospital of Nanjing University Medical School) Shao Xiaoyan (State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Nanjing Drum Tower Hospital The Afliated Hospital of) Zhao Yuanjin (State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Nanjing Drum Tower Hospital The Afliated Hospital of) Gu Zhuxiao (State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Nanjing Drum Tower Hospital The Afliated Hospital of) Jiang Qing (State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Nanjing Drum Tower Hospital The Afliated Hospital of)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
268 - 281 (14page)
DOI
10.1186/s40824-022-00335-w

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Volumetric muscle loss (VML) due to various reasons may cause motor dysfunction and tissue engineering has been proposed for muscle regeneration. However, developing three-dimensional (3D) tissue-engineered scaffolds that can mimic oriented cell growth of muscle tissues are challenging for regeneration medicine. Herein, we propose a novel self-curling 3D oriented scaffold (SCOS) composed of fish derived gelatin methacrylate (GelMA) and fish scales for repairing skeletal muscles.Fish scales of tilapia were decellularized and decalcified. Then, SCOSs were constructed by ultraviolet-coating methylated fish gelatin on the back of fish scales. C2C12 myoblasts were cultured on SCOSs, and after induction of myogenic differentiation, SCOS/C2C12 transplants were prepared for in vivo experiments.Decellularized and decalcified fish scales (DDFSs) became soft and retained the original oriented microgroove surface structure that could induce oriented cell growth. SCOSs could self-curl into 3D structures when immersing in culture medium due to different swelling properties of fish GelMA and DDFSs. Cell experiments demonstrated that SCOSs enhanced the oriented growth and myogenic differentiation of C2C12 myoblasts. By integrating SCOSs and myogenic differentiated C2C12 myoblasts, the resultant SCOS/C2C12 transplants promoted de novo muscle regeneration and functional restoration of muscle activity in the mouse model of VML.Our results suggest that SCOSs loaded with myogenic differentiated C2C12 myoblasts can promote muscle regeneration in mice with skeletal muscle injuries, indicating application prospects of such scaffolds in muscle tissue engineering and other related fields.
#Bioinspired #Hydrogel #Cell orientation #Fish scale #Muscle regeneration

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