지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Muscle disorders arise from genetic factors or other external environmental influences, leading to muscle loss and decreased strength. Muscle disease is closely related to age, and with the global progression of aging, there is increas- ing interest in the prevention and treatment of muscle diseases among the elderly population. Muscles release various sub- stances during contraction and relaxation when exercising, and growth and differentiation are enhanced. Similar effects can be achieved by vibration stimulations of specific frequencies. To examine the response of muscle cells to vibration stimuli, an in vitro vibration device capable of setting various frequencies and amplitudes was developed for use with a 6-well plate. In vitro vibrational stimulation was applied to C2C12 myoblasts to quantify the growth and differentiation of myoblasts, as well as cell apoptosis. 10 Hz vibrational stimuli resulted in increases in ERK signaling and decreases in cell death. More- over, an increase in the number of exposures to vibration promoted cellular differentiation. In conclusion, 10 Hz vibrational stimuli have the potential to increase muscle growth and differentiation and reduce apoptosis in C2C12 myoblasts.
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