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논문 기본 정보

자료유형
학술저널
저자정보
Lim Heeji (Division of Vaccine Development Coordination Center for Vaccine Research National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheong) Jang Sundong (Division of Vaccine Development Coordination Center for Vaccine Research National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheong) In Hyun Ju (Division of Vaccine Development Coordination Center for Vaccine Research National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheong) Kim Kwangwook (Division of Vaccine Development Coordination Center for Vaccine Research National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheong) Choi Eun Bee (Division of Vaccine Development Coordination Center for Vaccine Research National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheong) Kim Soo Ji (Division of Vaccine Development Coordination Center for Vaccine Research National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheong) Lim Hye Jung (Division of Vaccine Development Coordination Center for Vaccine Research National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheong) Yim Min Su (Division of Vaccine Development Coordination Center for Vaccine Research National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheong) Ouh In-ohk (Division of Vaccine Development Coordination Center for Vaccine Research National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheong) Kim Byung Chul (Division of Vaccine Development Coordination Center for Vaccine Research National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheong) Do Hyeon Nam (Division of Vaccine Clinical Research Center for Vaccine Research National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheongju Kore) Lee June-Woo (Division of Vaccine Clinical Research Center for Vaccine Research National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheongju Kore) Kim Byoungguk (Division of Vaccine Clinical Research Center for Vaccine Research National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheongju Kore) Lee Yoo-kyoung (Division of Vaccine Development Coordination Center for Vaccine Research National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheong)
저널정보
대한감염학회 Infection and Chemotherapy Infection and Chemotherapy 제55권 제1호
발행연도
2023.3
수록면
99 - 104 (6page)
DOI
10.3947/ic.2022.0132

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초록· 키워드

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The immunogenicity of a heterologous vaccination regimen consisting of ChAdOx1 nCoV-19 (a chimpanzee adenovirus-vectored vaccine) followed by mRNA-1273 (a lipid–nanoparticle-encapsulated mRNA-based vaccine) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), specifically the omicron variant (B.1.1.529), is poorly studied. The aim of this study was to evaluate the neutralizing antibody activity and immunogenicity of heterologous ChAdOx1 nCoV-19 and mRNA-1273 prime-boost vaccination against wild-type (BetaCoV/Korea/KCDC03/2020), alpha, beta, gamma, delta, and omicron variants of SARS-CoV-2 in Korea. A 50% neutralizing dilution (ND50) titer was determined in serum samples using the plaque reduction neutralization test. Antibody titer decreased significantly at 3 months compared with that at 2 weeks after the 2nd dose. On comparing the ND50 titers for the above-mentioned variants of concerns, it was observed that the ND50 titer for the omicron variant was the lowest. This study provides insights into cross-vaccination effects and can be useful for further vaccination strategies in Korea.
#COVID-19 vaccine #Heterologous vaccination #Immunity #Omicron variant #Korea

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