Resveratrol pretreatment alleviates NLRP3 inflammasome-mediated cardiomyocyte pyroptosis by targeting TLR4/MyD88/NF-κB signaling cascade in coronary microembolization-induced myocardial damage

Chang-Jun Luo; Tao Li; Hao-Liang Li; You Zhou; Lang Li

doi:10.4196/kjpp.2023.27.2.143

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자료유형: 학술저널

저자정보: Chang-Jun Luo (Department of Cardiology The First Affiliated Hospital of Guangxi Medical University) Tao Li (Department of Cardiology The First Affiliated Hospital of Guangxi Medical University) Hao-Liang Li (Department of Cardiology The First Affiliated Hospital of Guangxi Medical University) You Zhou (Department of Cardiology The First Affiliated Hospital of Guangxi Medical University) Lang Li (Department of Cardiology The First Affiliated Hospital of Guangxi Medical University)

저널정보: 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제27권 제2호

발행연도: 2023.2

수록면: 143 - 155 (13page)

DOI: 10.4196/kjpp.2023.27.2.143

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Percutaneous coronary intervention and acute coronary syndrome are both closely tied to the frequently occurring complication of coronary microembolization (CME). Resveratrol (RES) has been shown to have a substantial cardioprotective influence in a variety of cardiac diseases, though its function and potential mechanistic involvement in CME are still unclear. The forty Sprague–Dawley rats were divided into four groups randomly: CME, CME + RES (25 mg/kg), CME + RES (50 mg/kg), and sham (10 rats per group). The CME model was developed. Echocardiography, levels of myocardial injury markers in the serum, and histopathology of the myocardium were used to assess the function of the cardiac muscle. For the detection of the signaling of TLR4/MyD88/NF-κB along with the expression of pyroptosisrelated molecules, ELISA, qRT-PCR, immunofluorescence, and Western blotting were used, among other techniques. The findings revealed that myocardial injury and pyroptosis occurred in the myocardium following CME, with a decreased function of cardiac, increased levels of serum myocardial injury markers, increased area of microinfarct, as well as a rise in the expression levels of pyroptosis-related molecules. In addition to this, pretreatment with resveratrol reduced the severity of myocardial injury after CME by improving cardiac dysfunction, decreasing serum myocardial injury markers, decreasing microinfarct area, and decreasing cardiomyocyte pyroptosis, primarily by blocking the signaling of TLR4/MyD88/NF-κB and also reducing the NLRP3 inflammasome activation. Resveratrol may be able to alleviate CME-induced myocardial pyroptosis and cardiac dysfunction by impeding the activation of NLRP3 inflammasome and the signaling pathway of TLR4/MyD88/NF-κB

#Coronary microembolization #NLRP3 #Pyroptosis #Resveratrol #TLR4/MyD88/NF-κB

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