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논문 기본 정보

자료유형
학술저널
저자정보
Park Soohyung (Division of Cardiology Department of Medicine Korea University Guro Hospital Seoul Korea.) Battumur Byambakhand (Division of Cardiology Department of Medicine Korea University Guro Hospital Seoul Korea.) Yoon Seo Yeon (Department of Rehabilitation Medicine Korea University Guro Hospital Seoul Korea.) Lee Yohan (Sport Medicine Center Korea University Guro Hospital Seoul Korea.) Park Se hyun (Sport Medicine Center Korea University Guro Hospital Seoul Korea.) Lee Kyuho (Division of Cardiology Department of Medicine Korea University Guro Hospital Seoul Korea.) Back Seungmin (Division of Cardiology Department of Medicine Korea University Guro Hospital Seoul Korea.) Lee Jieun (Division of Cardiology Department of Medicine Korea University Guro Hospital Seoul Korea.) Kang Dong Oh (Division of Cardiology Department of Medicine Korea University Guro Hospital Seoul Korea.) Choi Jah Yeon (Division of Cardiology Department of Medicine Korea University Guro Hospital Seoul Korea.) Roh Seung-Young (Division of Cardiology Department of Medicine Korea University Guro Hospital Seoul Korea.) Na Jin Oh (Division of Cardiology Department of Medicine Korea University Guro Hospital Seoul Korea.) Choi Cheol Ung (Division of Cardiology Department of Medicine Korea University Guro Hospital Seoul Korea.) Kim Jin Won (Division of Cardiology Department of Medicine Korea University Guro Hospital Seoul Korea.) Rha Seung-Woon (Division of Cardiology Department of Medicine Korea University Guro Hospital Seoul Korea.) Park Chang Gyu (Division of Cardiology Department of Medicine Korea University Guro Hospital Seoul Korea.) Kim Eung Ju (Division of Cardiology Department of Medicine Korea University Guro Hospital Seoul Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.38 No.23
발행연도
2023.6
수록면
1 - 13 (13page)
DOI
10.3346/jkms.2023.38.e179

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Background: Exercise capacity is known to be an independent predictor of cardiovascular events and mortality. However, most previous studies were based on Western populations. Further study is warranted for Asian patients according to ethnic or national standards. We aimed to compare prognostic values of Korean and Western nomograms for exercise capacity in Korean patients with cardiovascular disease (CVD). Methods: In this retrospective cohort study, we enrolled 1,178 patients (62 ± 11 years; 78% male) between June 2015 and May 2020, who were referred for cardiopulmonary exercise testing in our cardiac rehabilitation program. The median follow-up period was 1.6 years. Exercise capacity was measured in metabolic equivalents by direct gas exchange method during the treadmill test. The nomogram for exercise capacity from healthy Korean individuals and a previous landmark Western study was used to determine the percentage of predicted exercise capacity. The primary endpoint was the composite of major adverse cardiovascular events (MACE; all-cause death, myocardial infarction, repeat revascularization, stroke and hospitalization for heart failure). Results: A multivariate analysis showed that the risk of primary endpoint was more than double (hazard ratio [HR], 2.20; 95% confidence interval [CI], 1.10–4.40) in the patients with lower exercise capacity (< 85% of predicted) by Korean nomogram. The lower exercise capacity was one of the strong independent predictors along with left ventricular ejection fraction, age, and level of hemoglobin. However, the lower exercise capacity by Western nomogram could not predict the primary endpoint (HR, 1.33; 95% CI, 0.85–2.10). Conclusion: Korean patients with CVD with lower exercise capacity have higher risk of MACE. Considering inter-ethnic differences in cardiorespiratory fitness, the Korean nomogram provides more suitable reference values than the Western nomogram to determine lower exercise capacity and predict cardiovascular events in Korean patients with CVD.

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