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논문 기본 정보

자료유형
학술저널
저자정보
Lee Eunyoung (Department of Internal Medicine Seoul Metropolitan Government-Seoul National University Boramae Medical Center Seoul Korea.) Park Sehee (National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheongju Korea.) Choi Jae-Phil (Division of Infectious Diseases Seoul Medical Center Seoul Korea.) Kim Min-Kyung (Division of Infectious Diseases National Medical Center Seoul Korea.) Yang Eunmi (Division of Infectious Diseases Seoul Medical Center Seoul Korea.) Ham Sin Young (Seoul Veterans Hospital Medical Center Seoul Korea.) Lee Seungjae (Seoul Veterans Hospital Medical Center Seoul Korea.) Lee Bora (Division of Pulmonary and Critical Care Medicine Department of Internal Medicine National Medical Center Seoul Korea.) Yang Jeong-Sun (National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheongju Korea.) Park Byoung Kwon (National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheongju Korea.) Kim Da Sol (National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheongju Korea.) Lee So-Young (National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheongju Korea.) Lee Joo-Yeon (National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheongju Korea.) Jang Hee-Chang (National Institute of Infectious Diseases Korea National Institute of Health Korea Disease Control and Prevention Agency Cheongju Korea.) Jeon Jaehyun (Division of Infectious Diseases National Medical Center Seoul Korea.) Park Sang-Won (Department of Internal Medicine Seoul Metropolitan Government-Seoul National University Boramae Medical Center Seoul Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.38 No.8
발행연도
2023.2
수록면
1 - 12 (12page)
DOI
10.3346/jkms.2023.38.e59

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Background: Information on the effectiveness of nirmatrelvir/ritonavir against the omicron is limited. The clinical response and viral kinetics to therapy in the real world need to be evaluated. Methods: Mild to moderate coronavirus disease 2019 (COVID-19) patients with risk factors for severe illness were prospectively enrolled as a treatment group with nirmatrelvir/ritonavir therapy versus a control group with supportive care. Serial viral load and culture from the upper respiratory tract were evaluated for seven days, and clinical responses and adverse reactions were evaluated for 28 days. Results: A total of 51 patients were analyzed including 40 in the treatment group and 11 in the control group. Faster symptom resolution during hospitalization (P = 0.048) was observed in the treatment group. Only minor adverse reactions were reported in 27.5% of patients. The viral load on Day 7 was lower in the treatment group (P = 0.002). The viral culture showed a positivity of 67.6% (25/37) vs. 100% (6/6) on Day 1, 0% (0/37) vs. 16.7 (1/6) on Day 5, and 0% (0/16) vs. 50.0% (2/4) on Day 7 in the treatment and control groups, respectively. Conclusions: Nirmatrelvir/ritonavir against the omicron was safe and resulted in negative viral culture conversion after Day 5 of treatment with better symptomatic resolution.
#Viral Load #Culture #Omicron #COVID-19 #Nirmatrelvir/Ritonavir

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