지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 111 - 117 (7page)
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초록· 키워드
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Objective: To evaluate the prognostic implication of human papillomavirus (HPV) viral load in cervical cancer patients whounderwent radical hysterectomy.
Methods: We conducted a retrospective review of patients with stage IA2 through stage IIIA cervical carcinoma who underwentradical hysterectomy at Sun Yat-sen University Cancer Center between January 2005 and December 2009. Patients who hadundergone preoperative hybrid capture 2 testing to detect HPV DNA were included. A total of 346 patients positive for HPVDNA were enrolled and stratified into two groups according to the median HPV viral load.
Results: HPV viral load was significantly correlated with lymphovascular space invasion (p=0.026) and deep stromal invasion(p=0.024). However, other factors, such as age, stage, histologic grade, histologic type, lymph node metastasis, and tumor size,were not significantly associated with viral load. Low HPV viral load was correlated with poor disease-free survival in univariateanalysis (p=0.037) and multivariate analysis (p=0.027). There was no significant difference in overall survival with regard to initialHPV viral load.
Conclusion: Low initial HPV viral load may be a poor prognostic factor for cervical cancer patients who have undergone radicalhysterectomy.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Sandri MT / 2006 / Comparison of the Digene HC2 assay and the Roche AMPLICOR human papillomavirus (HPV) test for detection of high-risk HPV genotypes in cervical samples / J Clin Microbiol 44:2141~2146
Origoni M / 2012 / Human papillomavirus viral load expressed as relative light units (RLU) correlates with the presence and grade of preneoplastic lesions of the uterine cervix in atypical squamous cells of undetermined significance (ASCUS) cytology / Eur J Clin Microbiol Infect Dis 31:2401~2406
Park JY / 2008 / The association of pre-conization high-risk HPV load and the persistence of HPV infection and persistence/recurrence of cervical intraepithelial neoplasia after conization / Gynecol Oncol 108:549~554
Wu Y / 2006 / Associations of high-risk HPV types and viral load with cervical cancer in China / J Clin Virol 35:264~269
Ho CM / 2006 / Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix / Br J Cancer 95:1384~1389
Origoni M / 2012 / Human papillomavirus viral load expressed as relative light units (RLU) correlates with the presence and grade of preneoplastic lesions of the uterine cervix in atypical squamous cells of undetermined significance (ASCUS) cytology / Eur J Clin Microbiol Infect Dis 31:2401~2406
Park JY / 2008 / The association of pre-conization high-risk HPV load and the persistence of HPV infection and persistence/recurrence of cervical intraepithelial neoplasia after conization / Gynecol Oncol 108:549~554
Wu Y / 2006 / Associations of high-risk HPV types and viral load with cervical cancer in China / J Clin Virol 35:264~269
Ho CM / 2006 / Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix / Br J Cancer 95:1384~1389
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