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자료유형
학술저널
저자정보
Martins Vanessa Gonzalez Ferreira Caminha (Brazilian Nuclear Energy Commission Nuclear Engineering Institute Brazil) Alencar Luciana Magalhaes Rebelo (Federal University of Maranhão Brazil) Souza Pedro Filho Noronha (Federal University of Ceará Brazil) Lorentino Carolinne Margot Albanez (Federal University of Rio de Janeiro Brazil) Frota Heloisa Freire (Federal University of Rio de Janeiro Brazil) dos Santos Andre Luis Souza (Federal University of Rio de Janeiro Brazil) Gemini-Piperni Sara (Federal University of Rio de Janeiro Brazil) Morandi Veronica (State University of Rio de Janeiro (UERJ) Brazil) Rodrigues Vinicius Gonçalves (Federal University of Goiás (UFG) Brasil) Pereira Jonathas Xavier (Federal University of Goiás (UFG) Brasil) Ricci-Junior Eduardo (Federal University of Rio de Janeiro Brazil) de Barros Aline Oliveira da Silva (Brazilian Nuclear Energy Commission Nuclear Engineering Institute Brazil) Santos-Oliveira Ralph (Brazilian Nuclear Energy Commission Nuclear Engineering Institute Brazil)
저널정보
한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제53권 제2호
발행연도
2023.3
수록면
333 - 342 (10page)
DOI
10.1007/s40005-023-00612-3

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Purpose The costs and complexity related to effective wound healing treatment are immense. The number of multifactorial aspects related to the treatment of wounds (inflammation, infection, and many others) implies a complex multi-therapeutic approach involving various procedures, including medication and surgery. Regarding medication, there are only a few options, especially to treat chronic wounds. Recently graphene quantum dots have been applied for their potent antimicrobial properties as well as their significant tissue remodeling properties. In this study, we developed a formulation based on graphene quantum dots in the form of as a dry powder for wound healing. Methods Graphene quantum dots were produced by top-down technique using graphite as matrix, and fully characterized by Raman spectroscopy, atomic force microscopy, and X-ray diffractometry. The dry powder formulation was produced under aseptic conditions and evaluated in vitro and in vivo. Results The results showed that the formulation improved the healing process in both: in vitro and in vivo, with good adherence, healing time and tissue reconstruction. Finally, the results demonstrated that dry powder was very effective against P. aeruginosa, S. epidermidis, C. albicans and C. tropicalis, representing an improvementfor wound healing purposes. Conclusion The data corroborated the use of the dry powder formulation using graphene quantum dots as matrix as wound dressing, expanding the use of graphene quantum in the biomedical field.

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