지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.6
- 수록면
- 56 - 60 (5page)
이용수
초록· 키워드
오류제보하기
Coptidis Rhizoma (CR) has been used widely in traditional medicine to treat common diseases. This study aimed to develop a high-sensitivity liquid chromatography-tandem mass (LC-MS) spectrometry method for the evaluation of the pharmacokinetics of a new natural product that contain CR extract with the main bioactive compound, berberine, at trace concentrations. Human plasma samples were pretreated with methanol by a protein precipitation method. Berberine was analyzed on a Kinetex C18 column (2.1 mm × 50 mm, 100 Å, 1.7 μm) using a mobile phase of 10 mM ammonium formate/0.1% formic acid in water (A) and acetonitrile (B) (50:50, v/v) with a flow rate of 0.25 mL/min. The analyte was detected by using electrospray ionization in positive mode with multiple reaction monitoring (MRM). The method was sensitive, with a lower limit of quantification of 1 pg/mL, which has not been previously obtained. The method was validated (over the range of 1–50 pg/mL) and applied successfully for the pharmacokinetic study of human plasma samples.
목차
Abstract
Introduction
Experimental
Results
Conclusions
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A sensitive and rapid LC-MS method for determination of berberine in human plasma
한국분석과학회 학술대회
2019 .05
-
Development and validation of a selective and sensitive LC-MS/MS method for determination of misoprostol acid in human plasma : Application to bioequivalence study
분석과학
2015 .02
-
Determination of clarithromycin in human plasma by LC-MS/MS : Validation and application in pharmacokinetic study
한국분석과학회 학술대회
2016 .05
-
Simultaneous Liquid Chromatography Tandem Mass Spectrometric Determination of 35 Prohibited Substances in Equine Plasma for Doping Control
Mass Spectrometry Letters
2022 .12
-
Berberine Induces p53-Dependent Apoptosis through Inhibition of DNA Methyltransferase3b in Hep3B Cells
대한임상검사과학회지
2020 .01
-
Liquid Chromatography-Tandem Mass Spectrometry Analysis of Riboflavin in Beagle Dog Plasma for Pharmacokinetic Studies
Mass Spectrometry Letters
2020 .03
-
Development and Validation of an LC-MS/MS Method for Determination of Damaurone D in Rat Plasma and its Application to Pharmacokinetic Study in Rats
Mass Spectrometry Letters
2019 .03
-
Development of an LC-MS/MS Method for Curcumin and Its Application in Pharmacokinetic Studies
한국분석과학회 학술대회
2024 .11
-
Determination of Paclitaxel in human plasma by LC-MS/MS method
한국분석과학회 학술대회
2023 .05
-
Analysis of inotodiol in plasma using LC-MS/MS for pharmacokinetic study using non-compartment analysis
한국분석과학회 학술대회
2018 .11
-
Rapid determination of entecavir in rat plasma using protein precipitation and multiple reaction monitoring
한국분석과학회 학술대회
2022 .05
-
Rapid determination of entecavir in rat plasma using protein precipitation and multiple reaction monitoring
한국분석과학회 학술대회
2022 .05
-
Determination of Carbamazepine in human plasma by LC-MS/MS method
한국분석과학회 학술대회
2023 .05
-
A Simple and Efficient Method to Determine Montelukast in Rat Plasma Using Liquid-Liquid Extraction and Tandem Mass Spectrometry
Mass Spectrometry Letters
2020 .12
-
Determination of Telmisartan in Human Plasma by LC-MS/MS Method
한국분석과학회 학술대회
2023 .05
-
Simultaneous Determination of Statins in Human Urine by Dilute-and-Shoot- Liquid Chromatography-Mass Spectrometry
Mass Spectrometry Letters
2018 .12
-
낮은 GWP를 가진 CxF2xO 을 이용한 SiO2 식각 공정 특성에 관한 연구
한국진공학회 학술발표회초록집
2020 .02
-
Simple and sensitive assay for quantification of oseltamivir phosphate(TamifluⓇ) in human plasma using by LC-MS/MS : Application in bioequivalence study
한국분석과학회 학술대회
2017 .11
-
A novel normal-phase LC-MS/MS method for quantitative analysis of 23 amino acids without derivatization in human plasma
한국분석과학회 학술대회
2016 .05
-
Pharmacokinetic study of citrate plasticizers using LC-MS/MS analysis
한국분석과학회 학술대회
2019 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0