지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 179 - 185 (7page)
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초록· 키워드
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Collision-induced dissociation (CID) combined with electrospray ionization mass spectrometry (ESI-MS) was used to obtain structural information on rat islet amyloid polypeptide (rIAPP) monomers (M) and dimers (D) observed in the multiply charged state in the MS spectrum. MS/MS analysis indicated that the rIAPP monomers adopt distinct structures depending on the molecular ion charge state. Peptide bond dissociation between L<SUB>27</SUB> and P<SUB>28</SUB> was observed in the MS/MS spectra of rIAPP monomers, regardless of the monomer molecular ion charge state. MS/MS analysis of the dimers indicated that D<SUP>5+</SUP> comprised M<SUP>2+</SUP> and M<SUP>3+</SUP> subunits, and that the peptide bond dissociation process between the L<SUB>27</SUB> and P<SUB>28</SUB> residues of the monomer subunit was also maintained. The observation of (M+ b<SUB>27</SUB>)<SUP>4+</SUP> and (M+ y<SUB>10</SUB>)<SUP>3+</SUP> fragment ions were deduced to originate from the two different D<SUP>5+</SUP> complex geometries, the N-terminal and C-terminal interaction geometries, respectively. The fragmentation pattern of the [M<SUB>rIAPP</SUB> + M<SUB>hIAPP</SUB>]<SUP>5+</SUP> MS/MS spectrum showed that the interaction occurred between the two N-terminal regions of M<SUB>rIAPP</SUB> and M<SUB>hIAPP</SUB> in the heterogeneous dimer (hetero-dimer) D<SUP>5+</SUP> structure.
목차
Abstract
Introduction
Experimental
Results and Discussion
Conclusion
References
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