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논문 기본 정보

자료유형
학술저널
저자정보
Boon-Kiat Lee (Universiti Sains Malaysia) Pei Xu (Universiti Sains Malaysia) Uma-Mageswary Mageswaran (Universiti Sains Malaysia) Woo-Sik Jeong (Kyungpook National University) Engku Ismail Engku-Husna (Universiti Sains Malaysia) Kadir Muhammad-Nashriq (Universiti Sains Malaysia) Svetoslav Dimitrov Todorov (University of Sao Paulo) Guoxia Liu (CAS-TWAS Centre of Excellence for Biotechnology) Yong-Ha Park (Probionic) Siti Nurma Hanim Hadie (Universiti Sains Malaysia) Min-Tze Liong (Universiti Sains Malaysia)
저널정보
한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.28 No.3
발행연도
2023.9
수록면
293 - 301 (9page)

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Skin aging, which affects all living organisms, is associated with oxidative stress. Probiotics exhibit antioxidant properties by producing reactive metabolites that counter oxidative stress. We hypothesized that Limosilactobacillus fermentum USM 4189 (LF 4189) has antioxidative properties and may prevent skin aging. In the present study, we used a D-galactose senescence-induced rat model to evaluate the potential antioxidative capability of LF 4189. The results indicated that rats administered LF 4189 exhibited increased plasma antioxidative activity (P=0.004), lipid peroxidation capacity (P=0.007), and skin elasticity compared with untreated aged rats (P=0.005). LF 4189 prevented telomere length shortening (P<0.05), indicating the potential to prevent senescence. A higher apoptotic activity was observed in old rats compared with young rats, whereas LF 4189 reduced the expression of four antioxidative enzyme genes that function as radical scavengers (all P<0.05), suggesting that the LF 4189 group had a reduced need to scavenge free radicals. Our findings indicate the potential of probiotics, such as LF 4189, as an anti-aging dietary intervention with antioxidant potential to improve skin health.

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ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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