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Mycobacterium tuberculosis is one of fearful pathogens and has the ability to persist within its host. Its successful survivalis due to alterations in gene expression in response to environmental changes by two component systems (TCS), whichconsist of sensor histidine kinases (HK) and their cognate response regulators (RR). M. tuberculosis has twelve TCSs andfive orphan RRs. A typical TCS involves sensing of internal or external signals by a HK, leading to its autophosphorylation,followed by phosphoryl transfer to the cognate RR, which functions as a transcriptional activator. To understand thefunction and the mechanism of M. tuberculosis TCSs, the components of HKs and RRs are subjected on the structuralstudies and the results could be useful for new antituberculosis drug development. Here, structural features of HKs andRRs currently revealed from M. tuberculosis are summarized. Those include GAF and PAS domains for senor domains andATP binding domains from HKs, and the receiver and effector domains from RRs.
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참고문헌 (102)
참고문헌 신청
Abramovitch, R. B. / 2011 / aprABC: a Mycobacterium tuberculosis complex-specific locus that modulates pH-driven adaptation to the macrophage phagosome / Mol Microbiol 80:678~694
Albanesi, D. / 2009 / Structural plasticity and catalysis regulation of a thermosensor histidine kinase / Proc Natl Acad Sci USA 106:16185~16190
Ashby, M. K. / 2004 / Survey of the number of two-component response regulator genes in the complete and annotated genome sequences of prokaryotes / FEMS Microbiol Lett 231:277~281
Ashenberg, O. / 2013 / Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans / J Mol Biol 425:1198~1209
Bacon, J. / 2007 / Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture : identification of a novel wax ester / Microbiology 153:14335~11444
Albanesi, D. / 2009 / Structural plasticity and catalysis regulation of a thermosensor histidine kinase / Proc Natl Acad Sci USA 106:16185~16190
Ashby, M. K. / 2004 / Survey of the number of two-component response regulator genes in the complete and annotated genome sequences of prokaryotes / FEMS Microbiol Lett 231:277~281
Ashenberg, O. / 2013 / Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans / J Mol Biol 425:1198~1209
Bacon, J. / 2007 / Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture : identification of a novel wax ester / Microbiology 153:14335~11444
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