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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 312 - 318 (7page)
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Objectives: Bacterial resistant infections have become a global health challenge and threaten the society’s health. Thus, an urgent need exists to find ways to combat resistant pathogens. One promising approach to overcoming bacterial resistance is the use of herbal products. Green tea catechins, the major green tea polyphenols, show antimicrobial activity against resistant pathogens. The present study aimed to investigate the effect of catechins, green tea extract, and methylxanthines in combination with gentamicin against standard and clinical isolates of Staphylococcus aureus (S. aureus) and the standard strain of Pseudomonas aeruginosa (P. aeruginosa).
Methods: The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) values of different agents against bacterial strains were determined. The interactions of green tea extract, epigallate catechin, epigallocatechin gallate, two types of methylxanthine, caffeine, and theophylline with gentamicin were studied in vitro by using a checkerboard method and calculating the fraction inhibitory concentration index (FICI).
Results: The MICs of gentamicin against bacterial strains were in the range of 0.312 - 320 μg/mL. The MIC values of both types of catechins were 62.5 - 250 μg/ mL. Green tea extract showed insufficient antibacterial activity when used alone. Methylxanthines had no intrinsic inhibitory activity against any of the bacterial strains tested. When green tea extract and catechins were combined with gentamicin, the MIC values of gentamicin against the standard strains and a clinical isolate were reduced, and synergistic activities were observed (FICI < 1). A combination of caffeine with gentamicin did not alter the MIC values of gentamicin.
Conclusion: The results of the present study revealed that green tea extract and catechins potentiated the antimicrobial action of gentamicin against some clinical isolates of S. aureus and standard P. aeruginosa strains. Therefore, combinations of gentamicin with these natural compounds might be a promising approach to combat microbial resistance.
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참고문헌 (30)
참고문헌 신청
Khameneh B / 2016 / Breakthroughs in bacterial resistance mechanisms and the potential ways to combat them / Microb Pathog 95:32~42
Khademi F / 2015 / Helicobacter pylori in Iran: a systematic review on the antibiotic resistance / Iran J Basic Med Sci 18(1):2~7
Riley MA / 2012 / Resistance is futile: The bacteriocin model for addressing the antibiotic resistance challenge / Biochem Soc Trans 40(6):1438~1442
Pantosti A / 2007 / Mechanisms of antibiotic resistance in Staphylococcus aureus / Future Microbiol 2(3):323~334
Corvec S / 2013 / Activities of fosfomycin, tigecycline, colistin, and gentamicin against extended-spectrum-lactamase-producing Escherichia coli in a foreign-body infection model / Antimicrob Agents Chemother 57(3):1421~1427
Khademi F / 2015 / Helicobacter pylori in Iran: a systematic review on the antibiotic resistance / Iran J Basic Med Sci 18(1):2~7
Riley MA / 2012 / Resistance is futile: The bacteriocin model for addressing the antibiotic resistance challenge / Biochem Soc Trans 40(6):1438~1442
Pantosti A / 2007 / Mechanisms of antibiotic resistance in Staphylococcus aureus / Future Microbiol 2(3):323~334
Corvec S / 2013 / Activities of fosfomycin, tigecycline, colistin, and gentamicin against extended-spectrum-lactamase-producing Escherichia coli in a foreign-body infection model / Antimicrob Agents Chemother 57(3):1421~1427
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