지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 231 - 236 (6page)
이용수
초록· 키워드
오류제보하기
Inhibition of Rho-associated coiled coil-containing kinase (ROCK) has been reported to promote differentiation of neuronal cells. Here, we examined the effect of Y-27632, a ROCK inhibitor, on the outgrowth of neurites in PC12 cells.
Y-27632 caused a rapid induction of neurite outgrowth in PC12 cells in a time-dependent manner. The neurite outgrowth, triggered by Y-27632, was accompanied by Rac1 activation, and was attenuated by Rac1 inhibitor NSC23766, in a concentration-dependent manner. Y-27632 also induced an increase in the production of reactive oxygen species (ROS). Pretreatment with N-acetylcysteine, an ROS scavenger, inhibited the ROS generation and neurite outgrowth in response to Y-27632. These results indicate that the activation of Rac1 and the generation of ROS contribute to the neurite outgrowth triggered by Y-27632 in PC12 cells.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Hirose M / 1998 / Molecular dissection of the Rhoassociated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells / J Cell Biol 141(7):1625~1636
Kubo T / 2008 / The therapeutic effects of Rho-ROCK inhibitors on CNS disorders / Ther Clin Risk Manag 4(3):605~615
Meihui Chen / 2013 / Fasudil and its analogs: a new powerful weapon in the long war against central nervous system disorders? / Expert Opinion on Investigational Drugs 22(4):537~550
Lars Tönges / 2011 / ROCKing regeneration: Rho kinase inhibition as molecular target for neurorestoration / Frontiers in Molecular Neuroscience 4
Z. Kouchi / 2011 / Phospholipase C 3 Regulates RhoA/Rho Kinase Signaling and Neurite Outgrowth / Journal of Biological Chemistry 286(10):8459~8471
Kubo T / 2008 / The therapeutic effects of Rho-ROCK inhibitors on CNS disorders / Ther Clin Risk Manag 4(3):605~615
Meihui Chen / 2013 / Fasudil and its analogs: a new powerful weapon in the long war against central nervous system disorders? / Expert Opinion on Investigational Drugs 22(4):537~550
Lars Tönges / 2011 / ROCKing regeneration: Rho kinase inhibition as molecular target for neurorestoration / Frontiers in Molecular Neuroscience 4
Z. Kouchi / 2011 / Phospholipase C 3 Regulates RhoA/Rho Kinase Signaling and Neurite Outgrowth / Journal of Biological Chemistry 286(10):8459~8471
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Neurite outgrowth effect of DUK102 in neuroblastoma neuro2a cells
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Propolis Inhibits Neurite Outgrowth in Differentiating SH-SY5Y Human Neuroblastoma Cells
Toxicological Research
2016 .07
-
Erratum to “Propolis Inhibits Neurite Outgrowth in Differentiating SH-SY5Y Human Neuroblastoma Cells” [Toxicol. Res. 32 (2016) 239-243]
Toxicological Research
2016 .10
-
DUK101 improves cognitive functions through the dendrite elongation of immature neuron in hippocampal dentate gyrus
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Pharmacological Activities and Applications of Spicatoside A
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Osseous outgrowth on the buccal maxilla associated with piezosurgery-assisted en-masse retraction : A case series
대한치과교정학회지
2018 .01
-
복신(茯神)의 인지기능 향상 및 해마 신경세포분화 촉진에 대한 효능 연구
대한본초학회지(본초분과학회지)
2015 .01
-
A Model of Glial Scarring Analogous to the Environment of a Traumatically Injured Spinal Cord Using Kainate
Annals of Rehabilitation Medicine
2016 .01
-
가미신추보건탕(加味伸椎步建湯)이 PC12 세포의 재생에 미치는 영향
논문집 : 대전대학교 한의학연구소. 한의학편
2016 .01
-
Silencing of Rac3 Inhibits Proliferation and Induces Apoptosis of Human Lung Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Efficient In Vitro Plasma Cell Differentiation by B Cell Receptor Activation and Cytokine Stimulation
Immune Network
2024 .10
-
The Role of Reactive Oxygen Species in Regulating T Cell-mediated Immunity and Disease
Immune Network
2018 .02
-
Sciatic nerve leachate of cattle causes neuronal differentiation of PC12 cells via ERK1/2 signaling pathway
Journal of Veterinary Science
2018 .07
-
Rac1 inhibition protects the kidney against kidney ischemia/reperfusion through the inhibition of macrophage migration
The Korean Journal of Physiology & Pharmacology
2023 .05
-
Centella asiatica enhances neurogenesis and protects neuronal cells against H2O2-induced oxidative injury
Journal of Biomedical and Translational Research
2015 .01
-
MS-5, a Naphthalene Derivative, Induces the Apoptosis of an Ovarian Cancer Cell CAOV-3 by Interfering with the Reactive Oxygen Species Generation
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Conditioned medium of E17 rat brain cells induced differentiation of primary colony of mice blastocyst into neuron-like cells
Journal of Veterinary Science
2021 .11
-
Reactive oxygen species overload: a review of plasma therapy and photobiomodulation for cancer treatment
MEDICAL LASERS
2023 .03
-
Anticancer activity and potential mechanisms of 1C, a ginseng saponin derivative, on prostate cancer cells
Journal of Ginseng Research
2018 .04
-
Dual mechanisms for the regulation of brain-derived neurotrophic factor by valproic acid in neural progenitor cells
The Korean Journal of Physiology & Pharmacology
2018 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0