지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제16권 제3호
- 발행연도
- 2015.1
- 수록면
- 121 - 128 (8page)
이용수
초록· 키워드
오류제보하기
Traditionally, Centella asiatica leaf extracts are used to treat neurodegenerative diseases in India. Centella asiatica is reportedly used to enhance memory and treat dementia, but its promoting effect on neural stem cell differentiation has not been studied yet. In the present study, we investigated whether or not Centella asiatica leaf extracts act on neuronal precursor cells and neuronal cell lines to induce neuronal differentiation, neurite outgrowth, and neuroprotection. The neurogenesis-promoting potential of Centella asiatica leaf extracts was determined by differentiation assay on neural stem cells isolated from mouse embryos and PC12 cell lines. To understand the contribution of specific neural cell types towards increase after Centella asiatica treatment, neural stem cells were differentiated into various neural subtypes and checked by Western blotting using neural cell lineage-specific antibody markers. Neuroprotective activity of Centella asiatica was analyzed in PC12 cells exposed to 100 μM of H2O2. Cell growth was analyzed by MTT assay while cell death was analyzed by Western blotting detection of apoptosis-related proteins. Cells treated with Centella asiatica had significantly longer primary and secondary neurites as well as a higher number of neurites per cell compared to control cells. Expression levels of TUBBIII, TH, NF, and BDNF increased upon Centella asiatica treatment, suggesting that Centella asiatica has a neurogenesis-promoting effect. Centella asiatica also inhibited oxidative stress-induced neural cell damage through regulation of apoptosis- and cell cycle-related proteins. Thus, leaf extracts of Centella asiatica might promote neurogenesis, neuroregeneration, and neuroprotection in the context of neurodegenerative diseases.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Acheson A / 1995 / A BDNF autocrine loop in adult sensory neurons prevents cell death / Nature 374:450~453
Bekinschtein P / 2008 / BDNF is essential to promote persistence of long-term memory storage / Proc Natl Acad Sci USA 105:2711~2716
James JT / 2009 / Pentacyclic Triterpenoids from the Medicinal Herb, Centella asiatica (L.) Urban / Molecules 14:3922~3941
Ning Y / 2015 / Oleanolic Acid Induces Differentiation of Neural Stem Cells to Neurons: An Involvement of Transcription Factor Nkx-2.5 / Stem Cells Int 2015:672312~672323
Suh N / 1999 / A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity / Cancer Res 59:336~341
Bekinschtein P / 2008 / BDNF is essential to promote persistence of long-term memory storage / Proc Natl Acad Sci USA 105:2711~2716
James JT / 2009 / Pentacyclic Triterpenoids from the Medicinal Herb, Centella asiatica (L.) Urban / Molecules 14:3922~3941
Ning Y / 2015 / Oleanolic Acid Induces Differentiation of Neural Stem Cells to Neurons: An Involvement of Transcription Factor Nkx-2.5 / Stem Cells Int 2015:672312~672323
Suh N / 1999 / A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity / Cancer Res 59:336~341
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
센텔라 아시아티카 정량추출물을 함유한 Water in Oil in Water (W<sub>1</sub>/O/W<sub>2</sub>) 에멀젼 제조에 관한 연구
대한화장품학회지
2015 .01
-
제주용암해수로 숙성된 병풀 추출물의 항염 및 보습 효과
대한화장품학회지
2019 .01
-
The Potential of Centella asiatica (Linn.) Urban as an Anti-Microbial and Immunomodulator Agent: A Review
Natural Product Sciences
2019 .06
-
Investigation of antioxidant effects in a Panax ginseng, Centella asiatica, Houttuynia cordata, and Lonicera japonica Mixture
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Biological Activities and Stability of a Standardized Pentacyclic Triterpene Enriched Centella asiatica Extract
Natural Product Sciences
2016 .03
-
Corrigendum: Magnolia Cortex, Centella Asiatica and Zea Mays L. Contained Dentifrice according to the Phase Influence to the Oral Environment
International Journal of Clinical Preventive Dentistry
2017 .01
-
Anti-inflammatory and anti-vascular leakage effects of centella asiatica extracts in LP-Sinduced Raw264.7 cell and vascular permeability mice model
한국실험동물학회 학술발표대회 논문집
2018 .07
-
스마트팜과 노지에서 재배한 병풀의 생약학적 비교
생약학회지(Korean Journal of Pharmacognosy)
2022 .12
-
Comparative effects of aqueous single-phase and oil-water two-phase mouthrinses containing bamboo salt, magnolia bark and Centella asiatica extracts on reducing gingivitis: a randomized clinical trial
대한구강보건학회지
2017 .09
-
Infection of Taenia asiatica in a Bai Person in Dali, China
Parasites, Hosts and Diseases
2016 .02
-
Centella asiatica attenuates radiation-induced enteropathy by modulating irradiated endothelial secretion
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Regulation of Neural Stem Cell Fate by Natural Products
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Cell Surface Antigen Display for Neuronal Differentiation-Specific Tracking
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Occurrence of a Hybrid Between Taenia saginata and Taenia asiatica Tapeworms in Cambodia
Parasites, Hosts and Diseases
2021 .04
-
Neural Stem Cells and Brain Diseases
한국실험동물학회 학술발표대회 논문집
2015 .08
-
석곡 및 병풀 복합 추출물의 피부 색소 침착 방지 및 피부재생 효과
생약학회지(Korean Journal of Pharmacognosy)
2022 .06
-
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes
Immune Network
2017 .06
-
Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
Parasites, Hosts and Diseases
2016 .10
-
Heterogeneity of Islet Cells during Embryogenesis and Differentiation
Diabetes and Metabolism Journal
2023 .03
-
채진목 에탄올 추출물의 항염증 효과 검증
대한화장품학회지
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0