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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 183 - 190 (8page)
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Anthricin (Deoxypodophyllotoxin), a naturally occurring flavolignan, has well known anti-cancer properties in several cancer cells, such as prostate cancer, cervical carcinoma and pancreatic cancer. However, the effects of Anthricin are currently unknown in oral cancer. We examined the anticancer effect and mechanism of action of Anthricin in human FaDu hypopharyngeal squamous carcinoma cells. Our data showed that Anthricin inhibits cell viability in a dose- and time-dependent manner (IC50 50 nM) in the MTT assay and Live & Dead assay. In addition, Anthricin treated FaDu cells showed marked apoptosis by DAPI stain and FACS.
Furthermore, Anthricin activates anti-apoptotic factors such as caspase-3, -9 and poly (ADP-ribose) polymerase (PARP), suggesting that caspase-mediated pathways are involved in Anthricin- induced apoptosis. Anthricin treatment also leads to accumulation of the pro-apoptotic factor Bax, followed by inhibition of cell growth. Taken together, these results indicate that Anthricn-induced cell death of human FaDu hypopharyngeal squamous carcinoma cells is mediated by mitochondrial-dependent apoptotic pathway. In summary, our findings provide a framework for further exploration on Anthricin as a novel chemotherapeutic drug for human oral cancer.
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참고문헌 (19)
참고문헌 신청
Greenlee RT / 2001 / Cancer statistics / CA Cancer J Clin 51:15~36
Daniele Maggioni / 2015 / Flavonoids in oral cancer prevention and therapy / European Journal of Cancer Prevention 24(6):517~528
Hopper C / 2004 / mTHPC-mediated photodynamic therapy for early oral squamous cell carcinoma / Int J Cancer 111:138~146
Synytsya A / 2008 / Glucans from fruit bodies of cultivated mushrooms Pleurotus ostreatus and Pleurotus eryngii structure and potential prebiotic activity / Carbohydr Polym :021
Yeonjoong Yong / 2009 / Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis / Bioorganic & Medicinal Chemistry Letters 19(15):4367~4371
Daniele Maggioni / 2015 / Flavonoids in oral cancer prevention and therapy / European Journal of Cancer Prevention 24(6):517~528
Hopper C / 2004 / mTHPC-mediated photodynamic therapy for early oral squamous cell carcinoma / Int J Cancer 111:138~146
Synytsya A / 2008 / Glucans from fruit bodies of cultivated mushrooms Pleurotus ostreatus and Pleurotus eryngii structure and potential prebiotic activity / Carbohydr Polym :021
Yeonjoong Yong / 2009 / Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis / Bioorganic & Medicinal Chemistry Letters 19(15):4367~4371
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