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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 61 - 68 (8page)
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Codium fragile (Suringar) Hariot is an edible green seaweed that belong to the Codiaceae family and has been used in Oriental medicine for the treatment of enterobiasis, dropsy, and dysuria. Methanol extract of codium fragile has anti-oxidant, anti-inflammatory and anti-cancer properties, although the anti-cancer effect on oral cancer has not yet been reported. In this study, we investigated the anti-cancer activity and the mechanism of cell death by methanol extracts of Codium fragile (MeCF) on human FaDu hypopharyngeal squamous carcinoma cells. Our data showed that MeCF inhibits cell viability in a dose-dependent manner, and markedly induced apoptosis, as determined by the MTT assay, Live/Dead assay, and DAPI stain. In addition, MeCF induced the proteolytic cleavage of procaspase -3, -7, -9 and poly(ADP-ribose) polymerase(PARP), and upregulated or downregulated the expression of mitochondrial-apoptosis factor, Bax(pro-apoptotic factor), and Bcl-2(anti-apoptotic factor), . Futhermore, MeCF induced a cell cycle arrest at the G1/S phase through suppressing the expression of the cell cycle cascade proteins, p21, CDK4, CyclinD1, and phospho-Rb. Taken together, these results indicated that MeCF inhibits cell growth, and this inhibition is mediated by caspase- and mitochondrial-dependent apoptotic pathways through cell cycle arrest at the G1/S phase in human FaDu hypopharyngeal squamous carcinoma cells. Therefore, methanol extracts of Codium fragile can be provided as a novel chemotherapeutic drug due to its growth inhibition effects and induction of apoptosis in human oral cancer cells.
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참고문헌 (19)
참고문헌 신청
이진석 / 2010 / 구강암 세포주를 이종 이식한 누드마우스에서 apigenin의 경구투여에 따른 항암효능에 관한 연구 / 생명과학회지 20(10):1519~1524
김원기 / 2016 / Anti-cancer Activity of Anthricin through Caspase-dependent Apoptosis in Human Hypopharyngeal Squamous Carcinoma Cell / International Journal of Oral Biology 41(4):183~190
Silverman S / 1990 / Epidemiologic and demographic update in oral cancer: California and national data-1973 to 1985 / J Am Dent Assoc 120:495~499
Hopper C / 2004 / mTHPCmediated photodynamic therapy for early oral squamous cell carcinoma / Int J Cancer 111:138~146
이은주 / 2006 / 구강암 세포주에서 COX-2억제제에 의한 세포성장 억제 효과 및 세포사멸 기전 연구 / 대한암예방학회지 11(2):89~98
김원기 / 2016 / Anti-cancer Activity of Anthricin through Caspase-dependent Apoptosis in Human Hypopharyngeal Squamous Carcinoma Cell / International Journal of Oral Biology 41(4):183~190
Silverman S / 1990 / Epidemiologic and demographic update in oral cancer: California and national data-1973 to 1985 / J Am Dent Assoc 120:495~499
Hopper C / 2004 / mTHPCmediated photodynamic therapy for early oral squamous cell carcinoma / Int J Cancer 111:138~146
이은주 / 2006 / 구강암 세포주에서 COX-2억제제에 의한 세포성장 억제 효과 및 세포사멸 기전 연구 / 대한암예방학회지 11(2):89~98
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