지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 356 - 362 (7page)
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초록· 키워드
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Purpose: To investigate long-term therapeutic effects and patient adherence to a combination therapy of a 5α-reductase inhibitor and an α-blocker and to identify causes of withdrawal from medication in patients with clinical benign prostatic hyperplasia (BPH).
Methods: BPH patients with lower urinary tract symptoms (LUTS) receiving combination therapy with follow-ups for 1?12 years were retrospectively analyzed. Therapeutic effects were assessed at baseline and annually by measuring International Prostatic Symptoms Score, quality of life index, total prostate volume (TPV), maximal flow rate, voided volume, postvoid residual volume and prostate-specific antigen level. Causes of discontinued combination therapy were also investigated.
Results: A total of 625 patients, aged 40?97 years (mean, 73 years) were retrospectively analyzed. All measured parameters showed significant improvements after combination therapy. Three hundred sixty-nine patients (59%) discontinued combination therapy with a mean treatment duration of 2.2 years. The most common reasons for discontinued treatment were changing medication to monotherapy with α-blockers or antimuscarinics (124 patients, 19.8%), receiving surgical intervention (39 patients, 6.2%), and LUTS improvement (53 patients, 8.5%). Only 64 patients (10.2%) were loss to follow-up and 6 (1.0%) discontinued combined treatment due to adverse effects. Smaller TPV after short-term combination treatment caused withdrawal from combination therapy.
Conclusions: BPH patients receiving long-term combination therapy showed significant improvement in all measured parameters.
Changing medication, improved LUTS and choosing surgery are common reasons for discontinuing combination herapy. A smaller TPV after short-term combination treatment was among the factors that caused withdrawal from combination therapy.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Jacobsen SJ / 2001 / Natural history of benign prostatic hyperplasia / Urology 58(6 Suppl 1):5~16
Emberton M / 2008 / Progression of benign prostatic hyperplasia: systematic review of the placebo arms of clinical trials / BJU Int 102:981~986
Emberton M / 2008 / Benign prostatic hyperplasia as a progressive disease: a guide to the risk factors and options for medical management / Int J Clin Pract 62:1076~1086
Djavan B / 1999 / A meta-analysis on the efficacy and tolerability of alpha1-adrenoceptor antagonists in patients with lower urinary tract symptoms suggestive of benign prostatic obstruction / Eur Urol 36:1~13
Lepor H / 1998 / The impact of medical therapy on bother due to symptoms, quality of life and global outcome, and factors predicting response. Veterans Affairs Cooperative Studies Benign Prostatic Hyperplasia Study Group / J Urol 160:1358~1367
Emberton M / 2008 / Progression of benign prostatic hyperplasia: systematic review of the placebo arms of clinical trials / BJU Int 102:981~986
Emberton M / 2008 / Benign prostatic hyperplasia as a progressive disease: a guide to the risk factors and options for medical management / Int J Clin Pract 62:1076~1086
Djavan B / 1999 / A meta-analysis on the efficacy and tolerability of alpha1-adrenoceptor antagonists in patients with lower urinary tract symptoms suggestive of benign prostatic obstruction / Eur Urol 36:1~13
Lepor H / 1998 / The impact of medical therapy on bother due to symptoms, quality of life and global outcome, and factors predicting response. Veterans Affairs Cooperative Studies Benign Prostatic Hyperplasia Study Group / J Urol 160:1358~1367
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