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논문 기본 정보

자료유형
학술저널
저자정보
김성민 (서울대학교) 범환 (서울대학교) Yun Ju Cho (Seoul National University) 어미영 (서울대학교) Ji Hyun Park (Korea Atomic Energy Research Institute) Byung Nam Kim (Korea Atomic Energy Research Institute) Byung Cheol Lee (Korea Atomic Ednergy Research Institute) 이석근 (강릉원주대학교)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제19권 제2호
발행연도
2015.6
수록면
83 - 92 (10page)
DOI
10.1186/s40824-015-0031-5

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Background: To develop biocompatible bony regeneration materials, allogenic, xenogenic and synthetic bones have been irradiated by an electron beam to change the basic structures of their inorganic materials. The optimal electron beam energy and individual dose have not been established for maximizing the bony regeneration capacity in electron beam irradiated bone. Results: Commercial products consisting of four allogenic bones, six xenogenic bones, and six synthetic bones were used in this study. We used 1.0-MeV and 2.0 MeV linear accelerators (power: 100 KW, pressure; 115 kPa, temperature; -30 to 120°C, sensor sensitivity: 0.1-1.2 mV/kPa, generating power sensitivity: 44.75 mV/kPa, supply voltage: 50.25 V), and a microtrone with different individual irradiation doses such as 60 kGy and 120 kGy. Additional in vitro analyses were performed by elementary analysis using field emission scanning electron microscopy (FE-SEM), scanning electron microscopy (SEM), X-ray diffraction (XRD) and confocal laser scanning microscopy (CLSM). In vivo clinical, radiographic, and micro-computed tomography (Micro-CT) with bone marrow density (BMD) analysis was performed in 8- and 16-week-old Spraque-Dawley rats with calvarial defect grafts.Conclusions: Electron beam irradiation of bony substitutes has four main effects: the cross-linking of biphasic calcium phosphate bony apatite, chain-scissioning, the induction of rheological changes, and microbiological sterilization. These novel results and conclusions are the effects of electron beam irradiation.

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