지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.6
- 수록면
- 341 - 346 (6page)
이용수
초록· 키워드
오류제보하기
Phagocytosis is a primary and an essential step of host defense, and is triggered by the interaction of particles with specific receptor of macrophages. In this study, we investigated the effect of extracts of Rudbeckia laciniata (RLE) on the phagocytic activity of macrophage, by monitoring the phagocytosis-associated signal transduction. RLE markedly increased phagocytosis of serum-opsonized zymosan particles (SOZ), while phagocytosis of IgG-opsonized zymosan particles (IOZ) or none-opsonized zymosan particles (NOZ) remained unaffected. However, RLE did not affect the binding of opsonized zymosan particles (OZ) with the cell surface of macrophage. This suggests that RLE may regulate SOZ-induced intracellular signaling during phagocytosis of macrophage. To confirm this hypothesis, we investigated whether RLE was involved in the RhoA-mediated signal transduction during phagocytosis of SOZ. Inhibitors of the RhoA-mediated signaling pathway, such as Y-27632 (for ROCK), ML-7 (for MLCK), and Tat-C3 (for RhoA), totally blocked phagocytosis of SOZ enhanced by RLE, as well as phagocytosis of SOZ. Additionally, RhoA activity was markedly increased when cells were treated with RLE, suggesting that RLE could increase the phagocytic activity of macrophage via RhoA-ROCK/MLCK signal pathway. Thus, RLE may be used to develop functional foods for immunity.
목차
등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
Aderem A / 1999 / Mechanisms of phagocytosis in macrophages / Annu Rev Immunol 17:593~623
안인정 / 2012 / 국화과 추출물의 암세포 증식 억제 효과 / 한국식품영양과학회지 41(5):584~590
Caron E / 1998 / Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases / Science 282:1717~1721
Castellano F / 2001 / Actin dynamics during phagocytosis / Semin Immunol 13:347~355
Chimini G1 / 2000 / Function of Rho family proteins in actin dynamics during phagocytosis and engulfment / Nat Cell Biol 2:191~196
안인정 / 2012 / 국화과 추출물의 암세포 증식 억제 효과 / 한국식품영양과학회지 41(5):584~590
Caron E / 1998 / Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases / Science 282:1717~1721
Castellano F / 2001 / Actin dynamics during phagocytosis / Semin Immunol 13:347~355
Chimini G1 / 2000 / Function of Rho family proteins in actin dynamics during phagocytosis and engulfment / Nat Cell Biol 2:191~196
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
삼잎국화 추출물의 피부세포 생리활성 효과
한국식품영양학회지
2016 .06
-
Yeast cell extracts from Saccharomyces cerevisiae promote immune response and phagocytosis in Raw 264.7 macrophages
한국식품영양과학회 학술대회발표집
2022 .10
-
Evaluation of Safety of Rudbeckia laciniata
한국식품영양과학회 학술대회발표집
2018 .10
-
Rhamnogalacturonan I-rich fractions from cherry tomatoes stimulate phagocytosis in RAW 264.7 macrophages
한국식품과학회지
2019 .06
-
Suppressed Phagocytosis and Pro-Inflammatory Cytokine Production by CLA Isomers in RAW264.7 Cells
한국식품영양과학회 학술대회발표집
2015 .08
-
LPS로 유도된 대식세포 RAWBlueTM에서 온주밀감 미숙과의 염증 관련 전사인자 NF-κB와 염증관련 단백질 iNOS, COX2 발현 억제 효과
한국원예학회 학술발표요지
2022 .11
-
The Chemical Compositions and Antioxidant Activities of Rudbeckia laciniata var.hortensis Extracts
한국식품영양과학회 학술대회발표집
2024 .10
-
Antioxidant Activity and Main Chemical Components of Rudbeckia laciniata Var. Hortensis
한국식품영양과학회 학술대회발표집
2019 .10
-
RAW264.7 대식세포에서 산양삼 추출물의 탐식능과 사이토카인 분비 증가에 의한 면역 활성 증진 효과
한국식품영양과학회지
2019 .06
-
Qualitative and Quantitative Analysis of Compounds in Rudbeckia laciniata var. hortensia using mass spectrometry
한국식품영양과학회 학술대회발표집
2018 .10
-
Aureobasidium pullulans으로 부터 분리한 β-1,3/1,6-glucan의 면역활성의 연구
Food Science and Preservation
2016 .12
-
A novel approach for dietary regulation of macrophages through mitochondrial energy metabolism
식품과학과 산업
2022 .09
-
청목폐(제품명)의 면역 증진 효과
농업생명환경연구
2021 .10
-
삼잎국화 분말을 첨가한 증편의 항산화 활성 및 품질특성
한국식품과학회지
2022 .08
-
Glycosaminoglycans Increase Phagocytic Ability of Macrophage through Activation of AMP-activated Protein Kinase
한국식품영양과학회 학술대회발표집
2015 .08
-
In Vitro Immunomodulatory Activity of Peptides Derived from Egg Yolk Proteins in RAW 264.7 Macrophages
한국식품영양과학회 학술대회발표집
2021 .10
-
Screening of various plant extracts for anti-inflammatory effects in alveolar macrophage cells
한국식품영양과학회 학술대회발표집
2018 .10
-
Antioxidant and Anti-inflammatory Effects of Plant Extracts in Alveolar Macrophages
한국식품영양과학회 학술대회발표집
2019 .10
-
Immunostimulatory effects of an aqueous extract of Chopi (Zanthoxylum piperitum) on a mouse macrophage cell line and peritoneal macrophages
한국식품영양과학회 학술대회발표집
2022 .10
-
Anti-inflammatory Effects of Korean Propolis Extracts on Raw264.7 Macrophage Cells
한국식품영양과학회 학술대회발표집
2018 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0