지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 722 - 727 (6page)
이용수
초록· 키워드
오류제보하기
Cardiomyopathy is a major cause of death worldwide. Based on pathohistological abnormalities and clinical manifestation, cardiomyopathies are categorized into several groups: hypertrophic, dilated, restricted, arrhythmogenic right ventricular, and unclassified. Dilated cardiomyopathy, which is characterized by dilation of the left ventricle and systolic dysfunction, is the most severe and prevalent form of cardiomyopathy and usually requires heart transplantation. Its etiology remains unclear. Recent genetic studies of single gene mutations have provided significant insights into the complex processes of cardiac dysfunction. To date, over 40 genes have been demonstrated to contribute to dilated cardiomyopathy. With advances in genetic screening techniques, novel genes associated with this disease are continuously being identified. The respective gene products can be classified into several functional groups such as sarcomere proteins, structural proteins, ion channels, and nuclear envelope proteins. Nuclear envelope proteins are emerging as potential molecular targets in dilated cardiomyopathy. Because they are not directly associated with contractile force generation and transmission, the molecular pathways through which these proteins cause cardiac muscle disorder remain unclear. However, nuclear envelope proteins are involved in many essential cellular processes. Therefore, integrating apparently distinct cellular processes is of great interest in elucidating the etiology of dilated cardiomyopathy. In this mini review, we summarize the genetic factors associated with dilated cardiomyopathy and discuss their cellular functions.
목차
등록된 정보가 없습니다.
참고문헌 (48)
참고문헌 신청
Arimura, T. / 2005 / Mouse model carrying H222P-Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies / Hum. Mol. Genet 14:155~169
Badorff, C. / 1999 / Enteroviral protease 2A cleaves dystrophin : evidence of cytoskeletal disruption in an acquired cardiomyopathy / Nat. Med 5:320~326
Bang, M. L. / 2001 / The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-disc to I-band linking system / Circ Res 89:1065~1072
Berko, B. A. / 1987 / X-linked dilated cardiomyopathy / N Engl. J. Med 316:1186~1191
Bienengraeber, M. / 2004 / ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating / Nat. Genet 36:382~387
Badorff, C. / 1999 / Enteroviral protease 2A cleaves dystrophin : evidence of cytoskeletal disruption in an acquired cardiomyopathy / Nat. Med 5:320~326
Bang, M. L. / 2001 / The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-disc to I-band linking system / Circ Res 89:1065~1072
Berko, B. A. / 1987 / X-linked dilated cardiomyopathy / N Engl. J. Med 316:1186~1191
Bienengraeber, M. / 2004 / ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating / Nat. Genet 36:382~387
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A novel nonsense mutation in NPR2 gene causing Acromesomelic dysplasia, type Maroteaux in a consanguineous family in Southern Punjab (Pakistan)
Genes & Genomics
2020 .01
-
Multi-scale Dilated Attention-based Generative Adversarial Network for Infrared and Visible Image Fusion
Current Optics and Photonics
2025 .04
-
Prediction of Nuclear Targeting Proteins with Nuclear Localization Signals in Staphylococcus aureus and Nuclear Targeting of β-lactamase in Host Cells
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .03
-
팽창된 잔차 합성곱신경망을 이용한 KOMPSAT-3A 위성영상의 융합 기법
대한원격탐사학회지
2020 .01
-
Gene expression profiling for seed protein and oil synthesis during early seed development in soybean
Genes & Genomics
2015 .01
-
A review of recent evidence of dietary protein intake and health
Nutrition Research and Practice
2022 .05
-
A review of recent evidence of dietary protein intake and health
Nutrition Research and Practice
2022 .05
-
Actn2 defects accelerates H9c2 hypertrophy via ERK phosphorylation under chronic stress
Genes & Genomics
2024 .09
-
Regional differences in protein intake and protein sources of Korean older adults and their association with metabolic syndrome using the 2016–2019 Korea National Health and Nutrition Examination Surveys: a cross-sectional study
대한지역사회영양학회지
2024 .06
-
Sequence Analysis of Hypothetical Proteins from Helicobacter pylori 26695 to Identify Potential Virulence Factors
Genomics & informatics
2016 .01
-
Effect of leucine-rich repeat kinase 2 (LRRK2) on protein synthesis
Animal cells and systems
2018 .01
-
Identification of novel alleles induced by EMS-mutagenesis in key genes of kernel hardness and starch biosynthesis in wheat by TILLING
Genes & Genomics
2017 .01
-
Network-Based Protein Biomarker Discovery Platforms
Genomics & informatics
2016 .01
-
Frontiers of biophysical techniques: unraveling molecular and cellular complexities
Biodesign
2024 .03
-
Mutations of the TATA-binding Protein Gene Improves Tolerance to Acetic Acid
한국미생물학회 학술대회논문집
2017 .04
-
How Do Bacteria Maximize Their Cellular Assets?
한국미생물·생명공학회지
2021 .12
-
De-novo Hybrid Protein Design for Biodegradation of Organophosphate Pesticides
한국미생물·생명공학회지
2019 .01
-
20-30대 성인의 건강관심도에 따른 단백질 보충 제품 이용 실태
동아시아식생활학회지
2025 .02
-
Standardization of protein concentration of brazzein, a tryptophan-deficient sweet protein by relative protein quantification using diverse methods
한국분석과학회 학술대회
2015 .11
-
Association between plant protein intake and grip strength in Koreans aged 50 years or older: Korea National Health and Nutrition Examination Survey 2016–2018
Nutrition Research and Practice
2023 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0