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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 154 - 161 (8page)
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A new generation of therapeutic antibody technologies has emerged last decade, most notable among which are bispecificantibodies and antibody-drug conjugates. Traditional monoclonal antibodies recognize a single target molecule and exerttheir therapeutic activity by neutralizing the target and/or through the effector functions. On the other hand, bispecificantibodies of various formats are able to bind two different targets simultaneously. Two major approaches to harnesstheir bispecific binding activity for therapeutic application are being pursued: recruitment of immune effector cells to thediseased cells, and simultaneous/synergistic neutralization of two disease-causing molecules. Antibody-drug conjugatesare disease-targeting monoclonal antibodies chemically conjugated to a highly cytotoxic compound. The internalizationof the conjugate by endocytosis and subsequent release of the cytotoxin result in a potent and selective cytotoxic activityagainst cancerous target cells. Optimization of the drug, linker, and conjugation chemistry is a major technologicalchallenge in developing antibody-drug conjugates. Despite their relatively recent emergence and technological difficulties,a few examples of these novel therapeutic modalities have been successfully developed and commercialized, and manyothers are in the late stages of clinical development. In this review, the background and the current status of technologicaldevelopment in this field is discussed, with emphasis on the detailed molecular design of these molecules.
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참고문헌 (64)
참고문헌 신청
Axup, J. Y. / 2012 / Synthesis of site-specific antibody-drug conjugates using unnatural amino acids / Proc Natl Acad Sci USA 109:16101~16106
Baselga, J. / 2001 / Clinical trials of Herceptin(R)(trastuzumab) / Eur J Cancer 37(Suppl 1):18~24
Blanc, V. / 2011 / SAR3419 : an anti-CD19-Maytansinoid Immunoconjugate for the treatment of B-cell malignancies / Clin Cancer Res 17:6448~6458
Boeggeman, E. / 2009 / Site specific conjugation of fluoroprobes to the remodeled Fc N-glycans of monoclonal antibodies using mutant glycosyltransferases : application for cell surface antigen detection / Bioconjug Chem 20:1228~1236
Buie, L. W. / 2015 / Blinatumomab : A First-in-Class Bispecific T-Cell Engager for Precursor B-Cell Acute Lymphoblastic Leukemia / Ann Pharmacother 49:1057~1067
Baselga, J. / 2001 / Clinical trials of Herceptin(R)(trastuzumab) / Eur J Cancer 37(Suppl 1):18~24
Blanc, V. / 2011 / SAR3419 : an anti-CD19-Maytansinoid Immunoconjugate for the treatment of B-cell malignancies / Clin Cancer Res 17:6448~6458
Boeggeman, E. / 2009 / Site specific conjugation of fluoroprobes to the remodeled Fc N-glycans of monoclonal antibodies using mutant glycosyltransferases : application for cell surface antigen detection / Bioconjug Chem 20:1228~1236
Buie, L. W. / 2015 / Blinatumomab : A First-in-Class Bispecific T-Cell Engager for Precursor B-Cell Acute Lymphoblastic Leukemia / Ann Pharmacother 49:1057~1067
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