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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.10
- 수록면
- 315 - 328 (14page)
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Activation of the unfolded protein response (UPR) in mammalian cells leads to cell cycle arrest at the G1 phase (Thomas et al., J Biol Chem 288:7606?7617, 2013). However, how UPR signaling affects cell cycle arrest remains largely unknown in plants. Here, we examined UPR and endoreduplication in Col-0, wee1, and ER stress sensing-deficient ire1a&b plants during DNA replication and ER stress conditions. We found that WEE1, an essential negative regulator of the cell cycle, is involved in the maintenance of ER homeostasis during genotoxic stress and the ER stress hypersensitivity of ire1a&b is alleviated by loss-of-function mutation in WEE1. WEE1-mediated cell cycle arrest was required for IRE1?bZIP60 pathway activation during ER stress. In contrast, loss-of-function mutation in WEE1 caused increased expression of UPR-related genes during DNA replication stress. WEE1 and IRE1 were required for endoreduplication during DNA replication stress and ER stress, respectively. Taken together, these findings suggest that cell cycle regulation is associated with UPR activation in different manners during ER stress and DNA replication stress in Arabidopsis.
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참고문헌 (61)
참고문헌 신청
Abraham RT / 2001 / Cell cycle checkpoint signaling through the ATM and ATR kinases / Genes Dev 15:2177~2196
Adachi S / 2011 / Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis / Proc Natl Acad Sci USA 108:10004~10009
Beemster GT / 2002 / Variation in growth rate between Arabidopsis ecotypes is correlated with cell division and A-type cyclin-dependent kinase activity / Plant Physiol 129:854~864
Bramsiepe J / 2010 / Endoreplication controls cell fate maintenance / PLoS Genet 6:e1000996
Celli J / 2015 / Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes? / Nat Rev Microbiol 13:71~82
Adachi S / 2011 / Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis / Proc Natl Acad Sci USA 108:10004~10009
Beemster GT / 2002 / Variation in growth rate between Arabidopsis ecotypes is correlated with cell division and A-type cyclin-dependent kinase activity / Plant Physiol 129:854~864
Bramsiepe J / 2010 / Endoreplication controls cell fate maintenance / PLoS Genet 6:e1000996
Celli J / 2015 / Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes? / Nat Rev Microbiol 13:71~82
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