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논문 기본 정보

자료유형
학술저널
저자정보
박인원 (Department of Emergency Medicine Seoul National University Bundang Hospital (SNUBH) Seongnam Korea.) 홍수정 (Graduate School of Nanoscience and Technology Korea Advanced Institute of Science and Technology (K) 석준 (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technolo) Stephani Edwina Lucia (KI for Health Science and Technology (KIHST) Korea Advanced Institute of Science and Technology (KA) 송은주 (Graduate School of Nanoscience and Technology Korea Advanced Institute of Science and Technology (K) 김민교 (Division of Rheumatology Department of Internal Medicine Gyeongsang National University School of M) 공은지 (KI for Health Science and Technology (KIHST) Korea Advanced Institute of Science and Technology (KA) 서호원 (Graduate School of Nanoscience and Technology Korea Advanced Institute of Science and Technology (K) 황윤하 (Graduate School of Nanoscience and Technology Korea Advanced Institute of Science and Technology) 안소연 (Graduate School of Nanoscience and Technology Korea Advanced Institute of Science and Technology (K) 김성혜 (Department of Emergency Medicine Seoul National University Bundang Hospital (SNUBH) Seongnam Korea.) 장동현 (Department of Emergency Medicine Seoul National University Bundang Hospital (SNUBH) Seongnam Korea;) 이재혁 (Department of Emergency Medicine Seoul National University Bundang Hospital (SNUBH) Seongnam Korea;) 박수형 (Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technolo) 김필한 (Graduate School of Nanoscience and Technology Korea Advanced Institute of Science and Technology () 조유환 (Department of Emergency Medicine Seoul National University Bundang Hospital (SNUBH) Seongnam Korea;)
저널정보
한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.24 No.5
발행연도
2021.10
수록면
463 - 473 (11page)
DOI
10.4048/jbc.2021.24.e40

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초록· 키워드

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Immunoreactive dynamics of tumor-infiltrating lymphocytes (TILs) within the tumor microenvironment in breast cancer are not well understood. This study aimed to investigate the spatiotemporal cellular dynamics of TILs in breast cancer models. Breast cancer cells were implanted into the dorsal skinfold chamber of BALB/c nude mice, and T lymphocytes were adoptively transferred. Longitudinal intravital imaging was performed, and the spatiotemporal dynamics of TILs were assessed. In the 4T1 model, TILs progressively exhibited increased motility, and their motility inside the tumor was significantly higher than that outside the tumor. In the MDA-MB-231 model, the motility of TILs progressively decreased after an initial increase. TIL motility in the MDA-MB-231 and MCF-7 models differed significantly, suggesting an association between programmed death-ligand 1 expression levels and TIL motility, which warrants further investigation. Furthermore, intravital imaging of TILs can be a useful method for addressing dynamic interactions between TILs and breast cancer cells.
#Breast neoplasms #Cell movement #Intravital microscopy #Lymphocytes #tumor-infiltrating #Programmed cell death 1 receptor

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참고문헌 (23)

참고문헌 신청
Kaiser J / 2018 / Cancer immunotherapy sweeps Nobel for medicine / Science 362:13 google schola Rosenberg SA / 2015 / Adoptive cell transfer as personalized immunotherapy for human cancer / Science 348:62~68 google schola Gajewski TF / 2013 / Innate and adaptive immune cells in the tumor microenvironment / Nat Immunol 14:1014~1022 google schola Krummel MF / 2010 / Illuminating emergent activity in the immune system by real-time imaging / Nat Immunol 11:554~557 google schola Salgado R / 2015 / The evaluation of tumor-infiltrating lymphocytes(TILs)in breast cancer : recommendations by an International TILs Working Group 2014 / Ann Oncol 26:259~271 google schola

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