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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 230 - 237 (8page)
- DOI
- 10.4285/kjt.21.0028
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초록· 키워드
오류제보하기
Background: The presence of preformed donor-specific antibodies in recipient serum against anti-human leukocyte antigen is a significant risk factor that negatively affects the outcomes of intestinal transplantation. Avoiding high-risk intestinal transplantation by physical and virtual cross matches has had limited success due to time constraints and ineffective correlation, respectively.
Methods: We developed a guideline to improve the association between physical and virtual cross matches using the retrospective data of 56 consecutive primary adult isolated intestinal transplantations from a single center.
Results: The mean fluorescence intensity of 2,000 for positive donor-specific antibodies revealed the best association between physical and virtual cross matches among different cut-off values, but with an unacceptable false positive rate of 54%. An enhanced virtual cross match with the summation of the mean fluorescence intensity of each anti- human leukocyte antigen improved the association between physical and virtual cross matches, with a sensitivity of 83% and specificity of 98%.
Conclusions: This enhanced virtual cross match more effectively predicts high-risk intestinal transplantation and is a better substitute for physical cross-match than the current virtual cross match. It also helps to avoid ill-considered abandonment of intestinal transplantation that is unnecessarily deemed high risk based on a simple virtual cross match.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Bond G / 2000 / The impact of positive T-cell lymphocytotoxic crossmatch on intestinal allograft rejection and survival / Transplant Proc 32:1197~1198
Abu-Elmagd KM / 2009 / Five hundred intestinal and multivisceral transplantations at a single center : major advances with new challenges / Ann Surg 250:567~581
Farmer DG / 2010 / Pretransplant predictors of survival after intestinal transplantation : analysis of a single-center experience of more than 100 transplants / Transplantation 90:1574~1580
Tsai HL / 2011 / Association between donor-specific antibodies and acute rejection and resolution in small bowel and multivisceral transplantation / Transplantation 92:709~715
Abu-Elmagd KM / 2012 / Preformed and de novo donor specific antibodies in visceral transplantation : long-term outcome with special reference to the liver / Am J Transplant 12:3047~3060
Abu-Elmagd KM / 2009 / Five hundred intestinal and multivisceral transplantations at a single center : major advances with new challenges / Ann Surg 250:567~581
Farmer DG / 2010 / Pretransplant predictors of survival after intestinal transplantation : analysis of a single-center experience of more than 100 transplants / Transplantation 90:1574~1580
Tsai HL / 2011 / Association between donor-specific antibodies and acute rejection and resolution in small bowel and multivisceral transplantation / Transplantation 92:709~715
Abu-Elmagd KM / 2012 / Preformed and de novo donor specific antibodies in visceral transplantation : long-term outcome with special reference to the liver / Am J Transplant 12:3047~3060
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