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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 28 - 32 (5page)
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초록· 키워드
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A 47-year-old man developed chronic alcoholic liver cirrhosis and end-stage renal disease. He underwent blood-type-compatible liver transplantation with a graft from his daughter. After 8 months, sequential ABO-incompatible (ABOi) kidney transplantation was performed, with his brother as the donor (A to O). The patient had anti-A antibody titers (1:256). We performed pretransplant desensitization, including administration of rituximab, mycophenolate mofetil, tacrolimus, and prednisolone 2 weeks before the scheduled transplantation, and plasmaphresis (PP) and administered an intravenous immunoglobulin injection. The patient underwent PP before kidney transplantation until the anti-A antibody titer was <1:8. The patient achieved normal renal function within 4 posttransplantation days. Postoperative bleeding (diffuse hemorrhage) requiring additional blood transfusions and radiological intervention (drainage procedure) occurred 9 days after transplantation. The patient was discharged on day 20 of hospitalization. Nine months after the kidney transplantation, the recipient’s and donor’s liver and kidney functions were normal.
ABOi renal transplantation after liver transplantation can be successfully performed in patients with high baseline anti-ABO antibody titers after preconditioning with rituximab and PP, and quadruple immunosuppressive therapy. However, caution is required regarding an increased risk of bleeding complications.
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등록된 정보가 없습니다.
참고문헌 (9)
참고문헌 신청
Bertelli R / 2008 / Kidney transplantation combined with other organs in Bologna: an update / Transplant Proc 40:1867~1868
Nakamura M / 2001 / Three cases of sequential liver-kidney transplantation from living-related donors / Nephrol Dial Transplant 16:166~168
Rahman T / 2006 / Plasmapheresis in nephrology: an update / Curr Opin Nephrol Hypertens 15:603~609
Tobian AA / 2009 / Therapeutic plasma exchange reduces ABO titers to permit ABO-incompatible renal transplantation / Transfusion 49:1248~1254
Shimmura H / 2005 / Lack of correlation between results of ABO-incompatible living kidney transplantation and anti-ABO blood type antibody titers under our current immunosuppression / Transplantation 80:985~988
Nakamura M / 2001 / Three cases of sequential liver-kidney transplantation from living-related donors / Nephrol Dial Transplant 16:166~168
Rahman T / 2006 / Plasmapheresis in nephrology: an update / Curr Opin Nephrol Hypertens 15:603~609
Tobian AA / 2009 / Therapeutic plasma exchange reduces ABO titers to permit ABO-incompatible renal transplantation / Transfusion 49:1248~1254
Shimmura H / 2005 / Lack of correlation between results of ABO-incompatible living kidney transplantation and anti-ABO blood type antibody titers under our current immunosuppression / Transplantation 80:985~988
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