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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 177 - 182 (6page)
- DOI
- 10.4285/kjt.21.0018
이용수
초록· 키워드
오류제보하기
Background: Some young adults have a long survival period with native liver after Kasai portoenterostomy (KPE) for biliary atresia (BA). However, a considerable proportion of these patients require liver transplantation (LT). This study aimed to analyze the indica- tions and outcomes of LT in young adults after a long survival period with native liver after KPE.
Methods: We selected seven patients who were 18 years or older at the time of LT out of 116 BA patients who underwent primary LT from 2008 to 2019 at Asan Medical Center. Results: The mean ages at KPE and LT were 2.1±0.9 months and 22.0±5.1 years, respec- tively. Mean serum total bilirubin level and model for end-stage liver disease score at LT were 7.91±7.22 mg/dL and 15.3±6.0, respectively. The main reasons for LT were liver cirrhosis with portal hypertension-associated complications in five patients and intracta- ble cholangitis in two patients. There were five cases of living donor LT and two cases of deceased donor LT. All the seven patients are currently alive during the mean follow-up period of 74.7±40.9 months. One patient suffered from outflow graft vein obstruction re- quiring endovascular stenting. Another patient showed core antibody-positivity-induced de novo hepatitis B virus infection, which was well managed with antiviral therapy. Conclusions: Young adult patients with BA are a unique group of patients requiring spe- cialist care regarding transition from pediatric to adult services. The outcomes of LT in young adult BA patients were excellent. Therefore, LT should be considered in patients showing serious BA-associated complications.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Livesey E / 2009 / Epidemiology of biliary atresia in England and Wales(1999-2006) / Arch Dis Child Fetal Neonatal Ed 94:F451~F455
Davenport M / 2011 / Biliary atresia in England and Wales : results of centralization and new benchmark / J Pediatr Surg 46:1689~1694
Bijl EJ / 2013 / The long-term outcome of the Kasai operation in patients with biliary atresia : a systematic review / Neth J Med 71:170~173
Lykavieris P / 2005 / Outcome in adulthood of biliary atresia : a study of 63 patients who survived for over 20 years with their native liver / Hepatology 41:366~371
Hsu EK / 2017 / Global lessons in graft type and pediatric liver allocation : a path toward improving outcomes and eliminating wait-list mortality / Liver Transpl 23:86~95
Davenport M / 2011 / Biliary atresia in England and Wales : results of centralization and new benchmark / J Pediatr Surg 46:1689~1694
Bijl EJ / 2013 / The long-term outcome of the Kasai operation in patients with biliary atresia : a systematic review / Neth J Med 71:170~173
Lykavieris P / 2005 / Outcome in adulthood of biliary atresia : a study of 63 patients who survived for over 20 years with their native liver / Hepatology 41:366~371
Hsu EK / 2017 / Global lessons in graft type and pediatric liver allocation : a path toward improving outcomes and eliminating wait-list mortality / Liver Transpl 23:86~95
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