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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 150 - 155 (6page)
- DOI
- https://doi.org/10.13041/jpvm.2017.41.4.150
이용수
초록· 키워드
오류제보하기
Turmeric is known for its ability to enhance immunity via anti-inflammatory and anti-oxidant effects. Salmonella enterica species contain a large number of pathogenic serotypes that are adapted to a broad range of vertebrate hosts. Our previous study revealed that bioprocessed polysaccharides from the liquid culture Lentinus edodes fungal mycelia containing turmeric (BPP-turmeric) is able to alter chicken macrophage responses and increases chick survival against Salmonella enterica infection. In this study, we examined the immunomodulatory effects of BPP-turmeric on the porcine macrophage 3D4/31 cell line infected with Salmonella enterica subsp. enterica serovar Choleraesuis (S. Choleraesuis) or S. Enteritidis. Our experimental analyses demonstrated that BPP-turmeric (i) does not alter phagocytic and killing activity of 3D4/31 against either Salmonella serotypes, but that it (ii) represses mRNA transcription of interleukin (IL)-6, IL-8, and tumor necrosis factor α in response to Salmonella infection. Collectively, these results imply that BPP-turmeric has an immunomodulatory effect that represses pro-inflammatory cytokine expression in porcine macrophages, suggesting that it may protect swine from salmonellosis via controlling Salmonella-induced hyperinflammation.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Bandyopadhyay D / 2014 / Farmer to pharmacist: Curcumin as an anti-invasive and antimetastatic agent for the treatment of cancer / Front Chem 2:113
Berge AC / 2012 / Nutritional strategies to combat Salmonella in mono-gastric food animal production / Animal 6:557~564
Bosmann M / 2013 / The inflammatory response in sepsis / Trends Immunol 34:129~136
Choudhary A / 2005 / Role of Salmonella surface components in immunomodulation of inflammatory mediators / Mol Cell Biochem 270:167~175
European Food Safety Authority / 2008 / Report of the Task Force on Zoonoses Data Collection on the Analysis of the baseline survey on the prevalence of Salmonella in slaughter pigs, Part B / The EFSA Journal 206:1~111
Berge AC / 2012 / Nutritional strategies to combat Salmonella in mono-gastric food animal production / Animal 6:557~564
Bosmann M / 2013 / The inflammatory response in sepsis / Trends Immunol 34:129~136
Choudhary A / 2005 / Role of Salmonella surface components in immunomodulation of inflammatory mediators / Mol Cell Biochem 270:167~175
European Food Safety Authority / 2008 / Report of the Task Force on Zoonoses Data Collection on the Analysis of the baseline survey on the prevalence of Salmonella in slaughter pigs, Part B / The EFSA Journal 206:1~111
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