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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1 - 6 (6page)
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Although the inflammatory response is vital for biological regulation, chronic inflammation damages the human body. Presently available anti-inflammatory drugs, including steroids, have side effects that prevent their administration to athletes. This study aimed at elucidating a method to control exercise-induced inflammation and oxidative stress, by investigating the anti-inflammatory and antioxidant efficacy of extracts of Albizia julibrissin fermented with kefir yogurt(FKA) in vitro. We investigated the effect of FKA on RAW 264.7 cells using cell viability assays. The regulatory effect of FKA in lipopolysaccharide(LPS)-induced nitric oxide(NO) production was determined using Griess reagent and the reverse transcription polymerase chain reaction(RT-PCR) assays, with specific primers such as interleukin(IL)-1β, IL-6, and IL-10, inducible nitric oxide synthase(iNOS), and cyclooxygenase- 2(COX-2) in vivo. Furthermore, the 2,2-diphenyl-1-picrylhydrazyl(DPPH) radical scavenging assay was performed and the cellular morphology changes were observed using florescence microscopy. The results showed that FKA significantly reduced LPS–induced NO production by regulating the expression of IL-1β, iNOS, and COX-2; thus, FKA exerts cytoprotective effects against ROS-induced cell death. These data suggest the anti-inflammatory therapeutic potential of FKA.
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참고문헌 (10)
참고문헌 신청
Muniandy K / 2018 / Suppres-sion of Proinflammatory Cytokines and Me-diators in LPS-induced RAW 264.7 Macro-phages by Stem Extract of Alternanthera Sessilis Via the Inhibition of the NF-κB Path-way / Journal of Immunology Research 3430684:1~12
Nathan C / 2013 / Beyond Oxidative Stress: An Immunologist's Guide to Reactive Oxygen Species / Nature Reviews Immunology 13(5):349~361
Serinkan BF / 2005 / Apoptotic Cells Quench Reactive Oxygen and Nitrogen Species and Modulate TNF-alpha/TGF-beta1 Balance in Activated Macrophages: Involvement of Phosphatidylserine-dependent and Inde-pendent Pathways / Cell Death & Differentia-tion 12(8):1141~1144
Leite AMO / 2013 / Micro-biological, Technological and Therapeutic Properties of Kefir: A Natural Probiotic Bev-erage / Brazilian Journal of Microbiology 44(2):341~349
Cai W / 2015 / Total Saponins from Albizia Julibris-sin Inhibit Vascular Endothelial Growth Fac-tor-mediated Angiogenesis in Vitro and In Vivo / Molecular Medicine Reports 11(5):3405~3413
Nathan C / 2013 / Beyond Oxidative Stress: An Immunologist's Guide to Reactive Oxygen Species / Nature Reviews Immunology 13(5):349~361
Serinkan BF / 2005 / Apoptotic Cells Quench Reactive Oxygen and Nitrogen Species and Modulate TNF-alpha/TGF-beta1 Balance in Activated Macrophages: Involvement of Phosphatidylserine-dependent and Inde-pendent Pathways / Cell Death & Differentia-tion 12(8):1141~1144
Leite AMO / 2013 / Micro-biological, Technological and Therapeutic Properties of Kefir: A Natural Probiotic Bev-erage / Brazilian Journal of Microbiology 44(2):341~349
Cai W / 2015 / Total Saponins from Albizia Julibris-sin Inhibit Vascular Endothelial Growth Fac-tor-mediated Angiogenesis in Vitro and In Vivo / Molecular Medicine Reports 11(5):3405~3413
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