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Statin Therapy and the Risk of Osteoporotic Fractures in Patients with Metabolic Syndrome: a Nested Case-Control Study
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논문 기본 정보

Type
Academic journal
Author
Kim Kyoung Jin (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University College o) Choi Jimi (Department of Biostatistics Korea University College of Medicine Seoul Korea.) Kim Ji Yoon (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University College o)
Journal
한국지질동맥경화학회(구 한국지질학회) 지질·동맥경화학회지 지질·동맥경화학회지 제10권 제3호 KCI Accredited Journals
Published
2021.9
Pages
322 - 333 (12page)
DOI
10.12997/jla.2021.10.3.322

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Statin Therapy and the Risk of Osteoporotic Fractures in Patients with Metabolic Syndrome: a Nested Case-Control Study
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Objective: We aimed to investigate the association between statin use and the risk of major osteoporotic fractures in patients with metabolic syndrome (MetS). Methods: A nested case-control study was performed in patients with MetS (≥50 years) who had no history of osteoporotic fracture using the Korean National Health Insurance Service- Health Screening Cohort. This study included 17,041 patients diagnosed with new-onset osteoporotic fractures and controls matched in a 1:1 ratio by age, sex, body mass index, cohort entry date, and follow-up duration. Conditional logistic regression analysis was used to evaluate covariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results: During a 4-year follow-up period, the risk of major osteoporotic fractures was significantly reduced by 9% (OR, 0.91; 95% CI, 0.85?0.97) in statin users compared with that in non-users. Among subtypes of major osteoporotic fracture, a risk reduction with statin therapy was significant for vertebral fracture (OR, 0.86; 95% CI, 0.79?0.94) but not for non-vertebral fracture (OR, 0.97; 95% CI, 0.88?1.06). Longer duration (OR, 0.97; 95% CI, 0.96?0.99, per 1-year increase) and higher cumulative dose (OR, 0.97; 95% CI, 0.95?0.99, per 365 defined daily doses) of statins were negatively associated with the risk of major osteoporotic fracture. Conclusion: This study supports the hypothesis that statin therapy has a beneficial effect on major osteoporotic fractures, especially vertebral fractures, in patients with MetS.
#HMG-CoA reductase inhibitor #Statin #Osteoporotic fractures #Metabolic syndrome #Case-control studies

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