지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 318 - 325 (8page)
- DOI
- 10.12701/yujm.2021.01018
이용수
초록· 키워드
오류제보하기
Background: The diagnosis and prediction of prognosis are important in patients with sepsis, and presepsin is helpful. In this study, we aimed to examine the usefulness of presepsin in predicting the prognosis of sepsis in Korea.
Methods: Patients diagnosed with sepsis according to the sepsis-3 criteria were recruited into the study and classified into surviving and non-surviving groups based on in-hospital mortality. A total of 153 patients (32 and 121 patients with sepsis and septic shock, respectively) were included from July 2019 to August 2020.
Results: Among the 153 patients with sepsis, 91 and 62 were in the survivor and non-survivor groups, respectively. Presepsin (p=0.004) and lactate (p=0.003) levels and the sequential organ failure assessment (SOFA) score (p<0.001) were higher in the non-survivor group. Receiver operating characteristic curve analysis revealed poor performances of presepsin and lactate in predicting the prognosis of sepsis (presepsin: area under the curve [AUC]=0.656, p=0.001; lactate: AUC=0.646, p=0.003). The SOFA score showed the best performance, with the highest AUC value (AUC=0.751, p<0.001). The prognostic cutoff point for presepsin was 1,176 pg/mL. Presepsin levels higher than 1,176 pg/mL (odds ratio [OR], 3.352; p<0.001), higher lactate levels (OR, 1.203; p=0.003), and higher SOFA score (OR, 1.249; p<0.001) were risk factors for in-hospital mortality.
Conclusion: Presepsin levels were higher in non-survivors than in survivors. Thus, presepsin may be a valuable biomarker in predicting the prognosis of sepsis.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Singer M / 2016 / The third international consensus definitions for sepsis and septic shock(Sepsis-3) / JAMA 315:801~810
Kim JH / 2012 / Influence of full-time intensivist and the nurse-to-patient ratio on the implementation of severe sepsis bundles in Korean intensive care units / J Crit Care 27:414
박대원 / 2012 / Epidemiological and Clinical Characteristics of Community- Acquired Severe Sepsis and Septic Shock: A Prospective Observational Study in 12 University Hospitals in Korea / Journal of Korean Medical Science 27(11):1308~1314
Annane D / 2013 / Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock : the CRISTAL randomized trial / JAMA 310:1809~1817
Rivers E / 2001 / Early goal-directed therapy in the treatment of severe sepsis and septic shock / N Engl J Med 345:1368~1377
Kim JH / 2012 / Influence of full-time intensivist and the nurse-to-patient ratio on the implementation of severe sepsis bundles in Korean intensive care units / J Crit Care 27:414
박대원 / 2012 / Epidemiological and Clinical Characteristics of Community- Acquired Severe Sepsis and Septic Shock: A Prospective Observational Study in 12 University Hospitals in Korea / Journal of Korean Medical Science 27(11):1308~1314
Annane D / 2013 / Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock : the CRISTAL randomized trial / JAMA 310:1809~1817
Rivers E / 2001 / Early goal-directed therapy in the treatment of severe sepsis and septic shock / N Engl J Med 345:1368~1377
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