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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 질병관리본부 Osong Public Health and Research Persptectives Osong Public Health and Research Perspectives 제12권 제5호
- 발행연도
- 2021.10
- 수록면
- 324 - 332 (9page)
- DOI
- 10.24171/j.phrp.2021.0207
이용수
초록· 키워드
오류제보하기
Objectives: The aims of this study were to investigate the expression of Yes-associated protein 1 (YAP1), its prognostic significance, and the correlation between YAP1 and telomerase in various cancers.Methods: The Gene Expression Profiling Interactive Analysis database was used to analyze RNA sequencing data and the survival rate of patients with various cancers in The Cancer Genome Atlas (TCGA) database. PrognoScan was used to analyze the prognostic value of YAP1 expression in various cancers. Tumor Immune Estimation Resource was used to determine the correlation between YAP1 expression and telomerase in various cancer types based on TCGA data.Results: The analysis suggested that YAP1 was differentially expressed between tissues of various cancers and non-tumor tissues. High YAP1 expression was also related to a poor prognosis in adrenocortical carcinoma, bladder urothelial carcinoma, and pancreatic adenocarcinoma. Moreover, YAP1 expression was correlated with the expression of telomerase reverse transcriptase and telomerase RNA component in various cancer types.Conclusion: These results suggest that YAP1 is a potential biomarker with prognostic significance and relevance for oncogene research in various cancer types. The correlation between the expression of YAP1 and telomere-associated genes will help to understand their cancer-promoting mechanisms and interactions.
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등록된 정보가 없습니다.
참고문헌 (55)
참고문헌 신청
Wang Y / 2010 / Overexpression of yes-associated protein contributes to progression and poor prognosis of non-smallcell lung cancer / Cancer Sci 101:1279~1285
Xu MZ / 2009 / Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma / Cancer 115:4576~4585
Zhao B / 2007 / Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control / Genes Dev 21:2747~2761
Orr BA / 2011 / Yes-associated protein 1 is widely expressed in human brain tumors and promotes glioblastoma growth / J Neuropathol Exp Neurol 70:568~577
Pan D / 2010 / The hippo signaling pathway in development and cancer / Dev Cell 19:491~505
Xu MZ / 2009 / Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma / Cancer 115:4576~4585
Zhao B / 2007 / Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control / Genes Dev 21:2747~2761
Orr BA / 2011 / Yes-associated protein 1 is widely expressed in human brain tumors and promotes glioblastoma growth / J Neuropathol Exp Neurol 70:568~577
Pan D / 2010 / The hippo signaling pathway in development and cancer / Dev Cell 19:491~505
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