지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 611 - 617 (7page)
- DOI
- 10.31616/asj.2020.0282
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초록· 키워드
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Study Design: This was a retrospective clinical study.
Purpose: This study aimed to evaluate the effect of combination therapy with zoledronic acid and teriparatide on the risk of new vertebral fracture (NVF) in type 2 diabetes mellitus (T2DM) patients after percutaneous kyphoplasty (PKP).
Overview of Literature: Although T2DM had been associated with bone fragility and increased fracture risk, it remains unknown whether patients with T2DM could expect similar benefit from the combination therapy with zoledronic acid and teriparatide following PKP.
Methods: Total 106 diabetic patients who had undergone PKP and had received anti-osteoporosis treatment for osteoporotic vertebral compression fracture were enrolled and allocated into the following two groups: group I (n=52, zoledronic acid) and group II (n=54, zoledronic acid plus teriparatide). The operating time, bone cement volume, and complications related to anti-osteoporosis treatment or PKP, if any, were recorded. The Visual Analog Scale (VAS) score and Oswestry Disability Index (ODI) were assessed at admission, at discharge, and at the final follow-up. Dual-energy X-ray absorptiometry scan of the hip for the measurement of the bone mineral density (BMD) was performed preoperatively and at the final follow-up for all the patients.
Results: There was no significant difference in the age, body mass index, bone cement volume, or follow-up time of the groups. The mean follow-up duration was 22.5±1.6 months. All the patients had improved VAS and ODI, and group II had significantly better clinical outcomes than group I. All the patients had increased BMD at the latest follow-up, while group II exhibited significantly more improvement. The prevalence of NVF was lower in group II (11.5% vs. 7.4%, p=0.523). Male patients had a higher prevalence of NVF although the difference was not statistically significant.
Conclusions: Combination therapy with zoledronic acid and teriparatide could improve the clinical outcomes, and BMD and had the potential to reduce NVF in diabetic patients following PKP.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Wang L / 2017 / Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013 / JAMA 317:2515~2523
Xu Y / 2013 / Prevalence and control of diabetes in Chinese adults / JAMA 310:948~959
Koromani F / 2020 / Vertebral fractures in individuals with type 2 diabetes : more than skeletal complications alone / Diabetes Care 43:137~144
Blasco J / 2012 / Effect of vertebroplasty on pain relief, quality of life, and the incidence of new vertebral fractures : a 12-month randomized follow-up, controlled trial / J Bone Miner Res 27:1159~1166
Lee DG / 2015 / Analysis of risk factors causing new symptomatic vertebral compression fractures after percutaneous vertebroplasty for painful osteoporotic vertebral compression fractures : a 4-year follow-up / J Spinal Disord Tech 28:E578~83
Xu Y / 2013 / Prevalence and control of diabetes in Chinese adults / JAMA 310:948~959
Koromani F / 2020 / Vertebral fractures in individuals with type 2 diabetes : more than skeletal complications alone / Diabetes Care 43:137~144
Blasco J / 2012 / Effect of vertebroplasty on pain relief, quality of life, and the incidence of new vertebral fractures : a 12-month randomized follow-up, controlled trial / J Bone Miner Res 27:1159~1166
Lee DG / 2015 / Analysis of risk factors causing new symptomatic vertebral compression fractures after percutaneous vertebroplasty for painful osteoporotic vertebral compression fractures : a 4-year follow-up / J Spinal Disord Tech 28:E578~83
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