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Transfusion Strategy of RhD-negative/variant Patients in the Korean Population
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RhD 음성/변이형 한국인 환자의 수혈전략

논문 기본 정보

Type
Academic journal
Author
양형석 (경희대학교) Sejong Chun (삼성서울병원) 이선아 (대한적십자사 중앙혈액검사센터) 권정란 (질병관리본부 혈액안전감시과) 최영실 (대한적십자사 중앙혈액검사센터) Jun Nyun Kim (질병관리본부 혈액안전감시과) CHO DEOK (삼성서울병원)
Journal
대한진단검사의학회 Laboratory Medicine Online Laboratory Medicine Online 제7권 제3호 KCI Accredited Journals
Published
2017.7
Pages
89 - 93 (5page)

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Transfusion Strategy of RhD-negative/variant Patients in the Korean Population
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Abstract· Keywords

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The prevalence of RhD-negative individuals in the Korean population is approximately 0.15-0.30% and the supply of RhD-negative blood often faces potential shortage. Furthermore, 15-17% of serologically RhD-negative Korean individuals were revealed to be DEL variants and should be treated as RhD-positive when being considered as blood donors. This change is expected to result in a further shortage of RhD-negative blood supply, whereas surplus DEL variant blood stock is created. Therefore, it is now required to amend blood donation and supply policies, and transfusion strategies. In this review, a new transfusion strategy for patients with RhD-negative or variant blood in Korea is discussed, with particular interest in women of child-bearing age, patients with anti-D, and Asia type DEL (c.1227G>A) variants.
#RHD #DEL #Transfusion #Genotyping

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References (30)

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Daniels G / 2008 / Human blood groups / John Wiley & Sons google schola Urbaniak SJ / 2000 / RhD haemolytic disease of the fetus and the newborn / Blood Rev 14:44~61 google schola Fung MK / 2014 / Technical manual / American Association of Blood Banks google schola Bowman JM / 1988 / The prevention of Rh immunization / Transfus Med Rev 2:129~150 google schola American College of Obstetricians and Gynecologists / 1999 / Prevention of Rh D alloimmunization / Practice bulletin 4 google schola

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