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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective: Cognitive reserve (CR) protects against cognitive decline by utilizing functional connectivity (FC) in the brain, such as the default mode network (DMN). We studied whether CR in individuals with predementia would correlate with better cognition and increased DMN FC in the resting brain.
Methods: Fifty-four participants with subjective cognitive decline or mild cognitive impairment completed the Cognitive Reserve Index (CRI) questionnaire, and underwent a comprehensive neuropsychological test battery and resting state functional magnetic resonance imaging. Correlation and regression analyses for clinical variables and seed-to-voxel analyses of CR-related FC in the DMN were conducted.
Results: CRI total (β=0.42, p=0.001), education (β=0.39, p=0.001), and leisure time (β=0.33, p=0.009) predicted the Mini- Mental State Examination. The CRI education predicted verbal memory recall (β=0.32, p=0.017), confrontational naming (β=0.57, p<0.001), and phonemic fluency (β=0.43, p=0.004). In the DMN in the resting brain, the CRI total correlated with increased FC, based on the posterior cingulate to both lateral parietal cortices.
Conclusion: In individuals with predementia, comprehensive CR correlated with an enhanced network in the DMN in the resting state. These results may support the neural correlate of CR during the initial stage of cognitive decline.
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참고문헌 (49)
참고문헌 신청
Livingston G / 2020 / Dementia prevention, intervention, and care: 2020 report of the Lancet Commission / Lancet 396:413~446
Stern Y / 2012 / Cognitive reserve in ageing and Alzheimer’s disease / Lan cet Neurol 11:1006~1012
Stern Y / 2020 / Whitepaper: defining and investigating cognitive reserve, brain reserve, and brain maintenance / Alzheimers Dement 16:1305~1311
Badhwar A / 2017 / Resting-state network dysfunction in Alzheimer’s disease: a systematic review and meta-analysis / Alzheimers Dement(Amst) 8:73~85
Agosta F / 2012 / Resting state fMRI in Alzheimer’s disease : beyond the default mode network / Neurobiol Aging 33:1564~1578
Stern Y / 2012 / Cognitive reserve in ageing and Alzheimer’s disease / Lan cet Neurol 11:1006~1012
Stern Y / 2020 / Whitepaper: defining and investigating cognitive reserve, brain reserve, and brain maintenance / Alzheimers Dement 16:1305~1311
Badhwar A / 2017 / Resting-state network dysfunction in Alzheimer’s disease: a systematic review and meta-analysis / Alzheimers Dement(Amst) 8:73~85
Agosta F / 2012 / Resting state fMRI in Alzheimer’s disease : beyond the default mode network / Neurobiol Aging 33:1564~1578
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