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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 379 - 383 (5page)
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We previously reported that p53 plays a role as a key regulator in the tetraploid G1 checkpoint, which is activated by actin damage-induced cytokinesis blockade and then prevents uncoupled DNA replication and nuclear division without cytokinesis. In this study, we investigated a role of Skp2, which targets CDK2 inhibitor p27/Kip1, in actin damage-induced tetraploid G1 arrest. Expression of Skp2 was reduced, but p27/Kip1 was increased, after actin damage-induced cytokinesis blockade. The role of Skp2 repression in tetraploid G1 arrest was investigated by analyzing the effects of ectopic expression of Skp2. After actin damage, ectopic expression of Skp2 resulted in DNA synthesis and accumulation of multinucleated cells, and ultimately, induction of apoptosis. These results suggest that Skp2 repression is important for sustaining tetraploid G1 arrest after cytokinesis blockade and is required to prevent uncoupled DNA replication and nuclear division without cytokinesis.
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참고문헌 (24)
참고문헌 신청
Hartwell LH / 1989 / Checkpoints: controls that ensure the order of cell cycle events / Science 246:629~634
Kuerbitz SJ / 1992 / Wild-type p53 is a cell cycle checkpoint determinant following irradiation / Proc Natl Acad Sci U S A 89:7491~7495
Bunz F / 1998 / Requirement for p53 and p21 to sustain G2 arrest after DNA damage / Science 282:1497~1501
Lanni JS / 1998 / Characterization of the p53-dependent postmitotic checkpoint following spindle disruption / Mol Cell Biol 18:1055~1064
Khan S / 1998 / p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest / Cancer Res 58:396~401
Kuerbitz SJ / 1992 / Wild-type p53 is a cell cycle checkpoint determinant following irradiation / Proc Natl Acad Sci U S A 89:7491~7495
Bunz F / 1998 / Requirement for p53 and p21 to sustain G2 arrest after DNA damage / Science 282:1497~1501
Lanni JS / 1998 / Characterization of the p53-dependent postmitotic checkpoint following spindle disruption / Mol Cell Biol 18:1055~1064
Khan S / 1998 / p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest / Cancer Res 58:396~401
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