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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 348 - 355 (8page)
- DOI
- 10.1007/s13206-021-00031-2
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초록· 키워드
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Ovarian cancer is the fifth leading cause of cancer-related deaths among women. In particular, it is a high cause of mortality among women in industrialized countries. Human epididymis protein 4 (HE4) has recently emerged as a serological biomarker for the diagnosis of ovarian cancer. Herein, we report the ultrasensitive detection of HE4 using a gold (Au) nanoplate (NPl)-based surface-enhanced Raman scattering (SERS) immunoassay, wherein a capture antibody-immobilized Au NPl acts as an immune substrate and detection antibody-immobilized Au nanoparticles (NPs) serve as immunoprobes. The presence of the target biomarker (HE4) results in the formation of a sandwich structure of Au NPls and NPs, providing strong SERS signals. The developed method allows us to detect HE4 at low concentrations of 10 ?17 ?M. The selective detection of HE4 was verified using the Au NPl SERS immunoassay. We anticipate that the current approach could be helpful for the early diagnosis of ovarian cancer and eventually applied for diverse biomarker detection.
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등록된 정보가 없습니다.
참고문헌 (56)
참고문헌 신청
Kong, S. Y. / 2012 / Serum HE4 level is an independent prognostic factor in epithelial ovarian cancer / Ann. Surg. Oncol 19:1707~1712
Ozols, R.F. / 2002 / Recurrent ovarian cancer: evidence-based treatment / J. Clin. Oncol 20:1161~1163
Drapkin, R. / 2005 / Human epididymis protein 4 (HE4)is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas / Cancer Res 65:2162~2169
Parkin, D. M. / 1999 / Estimates of the worldwide incidence of 25 major cancers in 1990 / Int. J. Cancer 80:827~841
Jemal, A. / 2008 / Cancer statistics, 2008 / CA Cancer J. Clin 58:71~96
Ozols, R.F. / 2002 / Recurrent ovarian cancer: evidence-based treatment / J. Clin. Oncol 20:1161~1163
Drapkin, R. / 2005 / Human epididymis protein 4 (HE4)is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas / Cancer Res 65:2162~2169
Parkin, D. M. / 1999 / Estimates of the worldwide incidence of 25 major cancers in 1990 / Int. J. Cancer 80:827~841
Jemal, A. / 2008 / Cancer statistics, 2008 / CA Cancer J. Clin 58:71~96
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