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논문 기본 정보

자료유형
학술저널
저자정보
Jiyoon Jeong (Asan Medical Center Children’s Hospital) Yoojin Kwun (독립연구자) 김민주 (서울아산병원) Sang-Ho Choi (University of Ulsan College of Medicine) Euiseok Jung (Asan Medical Center Children's Hospital) Byong Sop Lee (University of Ulsan) Ki-Soo Kim (울산대학교) Ellen Ai Rhan Kim (Asan Medical Center Children’s Hospital)
저널정보
대한신생아학회 Neonatal medicine Neonatal medicine 제28권 제3호
발행연도
2021.8
수록면
116 - 123 (8page)
DOI
https://doi.org/10.5385/nm.2021.28.3.116

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Purpose: The aim of this study was to estimate the effect of targeting risk factors for the control of central line-associated bloodstream infection (CLABSI) among high-risk infants in a tertiary neonatal intensive care unit (NICU). Methods: Infants admitted to the NICU and diagnosed with CLABSI from January to December 2013 were eligible for inclusion to the study. The CLABSI group (n=47) was matched in a 1:2 ratio to the control group (n=94) based on gestational age, birth weight, and Score for Neonatal Acute Physiology-II. Risk factors for CLABSI were identified using the Cox proportional hazard model, and analysis of the effect of these risk factors targeting infection control was performed. Results: The risk factors associated with CLABSI were prolonged central line dwell days (adjusted hazard ratio [HR], 1.028; 95% confidence interval [CI], 1.011 to 1.045; P=0.001), use of a silicone catheter (adjusted HR, 5.895; 95% CI, 1.893 to 18.355; P= 0.002), surgical treatment (adjusted HR, 3.793; 95% CI, 1.467 to 9.805; P=0.006), and less probiotic supplementation (adjusted HR, 0.254; 95% CI, 0.068 to 0.949; P=0.042). By targeting these risk factors with a quality improvement initiative, the mean CLABSI incidence rate per 1,000 catheter-days decreased from 6.6 to 3.1 (P=0.004). Conclusion: Targeting risk factors for infection control significantly reduced the rate of CLABSI among high-risk infants in the NICU.

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