Gastric Adenocarcinoma of Fundic Gland Type with Aggressive Transformation and Lymph Node Metastasis: a Case Report

Yasuhiro Okumura; Manabu Takamatsu; Manabu Ohashi; Yorimasa Yamamoto; Noriko Yamamoto; Hiroshi Kawachi; Satoshi Ida; Koshi Kumagai; Souya Nunobe; Naoki Hiki; Takeshi Sano

doi:10.5230/jgc.2018.18.e22

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자료유형: 학술저널

저자정보: Yasuhiro Okumura (Japanese Foundation for Cancer Research) Manabu Takamatsu (Japanese Foundation for Cancer Research) Manabu Ohashi (Japanese Foundation for Cancer Research) Yorimasa Yamamoto (Showa University Fujigaoka Hospital) Noriko Yamamoto (Japanese Foundation for Cancer Research) Hiroshi Kawachi (Japanese Foundation for Cancer Research) Satoshi Ida (Japanese Foundation for Cancer Research) Koshi Kumagai (Japanese Foundation for Cancer Research) Souya Nunobe (Japanese Foundation for Cancer Research) Naoki Hiki (Japanese Foundation for Cancer Research) Takeshi Sano (Japanese Foundation for Cancer Research)

저널정보: 대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제18권 제4호

발행연도: 2018.12

수록면: 409 - 416 (8page)

DOI: 10.5230/jgc.2018.18.e22

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A 55-year-old man visited our hospital for a detailed examination of a gastric submucosal tumor that was first detected 10 years prior. The tumor continued to grow and had developed a depressed area in its center. A histopathological examination of biopsy specimens revealed gastric adenocarcinoma of the fundic gland type (GA-FG). It was diagnosed as T2 based on the invasion depth as determined by white-light endoscopy and endoscopic ultrasonography. A total gastrectomy with lymphadenectomy was performed and a GA-FG in the mucosa and submucosa was confirmed histopathologically. However, there was a gradual transition to an infiltrative tubular adenocarcinoma with poorly differentiated components in the muscular and subserosal layers. Metastasis was identified in a dissected lymph node (LN). This is the first report of a GA-FG progressing to an aggressive cancer with LN metastasis. These findings modify our understanding of the pathophysiology of GA-FG.

#Gastric gland #Lymph nodes #Neoplasm metastasis

참고문헌 (17)

참고문헌 신청

Ueyama H / 2010 / Gastric adenocarcinoma of fundic gland type (chief cell predominant type): proposal for a new entity of gastric adenocarcinoma / Am J Surg Pathol 34:609~619

Ueyama H / 2014 / Gastric adenocarcinoma of the fundic gland type (chief cell predominant type) / Endoscopy 46:153~157

Miyazawa M / 2016 / Gastric adenocarcinoma of the fundic gland (chief cell-predominant type): a review of endoscopic and clinicopathological features / World J Gastroenterol 22:10523~10531

Sato Y / 2016 / Twelve-year natural history of a gastric adenocarcinoma of fundic gland type / Clin J Gastroenterol 9:345~351

Japanese Gastric Cancer Association / 2017 / Japanese Classification of Gastric Carcinoma / Kanehara Shuppan

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