Sarcopenia and Post-Operative Morbidity and Mortality in Patients with Gastric Cancer

Stephen O Brien; Maria Twomey; Fiachra Moloney; Richard G. Kavanagh; Brian W. Carey; Derek Power; Michael M. Maher; Owen J. OConnor; Criostoir ÓSúilleabháin

doi:https://doi.org/10.5230/jgc.2018.18.e25

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자료유형: 학술저널

저자정보: Stephen O Brien (Mercy University Hospital) Maria Twomey (Cork University Hospital) Fiachra Moloney (Cork University Hospital) Richard G. Kavanagh (Cork University Hospital) Brian W. Carey (Cork University Hospital) Derek Power (Mercy Cork University Hospitals) Michael M. Maher (Cork University Hospital) Owen J. OConnor (Cork University Hospital) Criostoir ÓSúilleabháin (Mercy University Hospital)

저널정보: 대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제18권 제3호

발행연도: 2018.9

수록면: 242 - 252 (11page)

DOI: https://doi.org/10.5230/jgc.2018.18.e25

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Purpose: Surgical resection for gastric adenocarcinoma is associated with significant post-operative morbidity and mortality. The aim of this study was to assess the prognostic significance of sarcopenia in patients undergoing resection for gastric adenocarcinoma with respect to post-operative morbidity and survival. Materials and Methods: A retrospective analysis was conducted on a cohort of consecutive patients who underwent surgical resection for gastric adenocarcinoma between 2008 and 2014. Patient demographics, radiological parameters, and pathological data were collected. OsiriX software (Pixmeo) was used to measure skeletal muscle area, which was normalized for height to calculate skeletal muscle index. Results: A total of 56 patients (41 male, 15 female; mean age, 68.4 ± 11.9 years) met the inclusion criteria. Of these, 36% (20 of 56) of the patients were sarcopenic pre-operatively. Both sarcopenic and non-sarcopenic patient groups were equally matched with the exception of weight and body mass index (P=0.036 and 0.001, respectively). Sarcopenia was associated with a decreased overall survival (log-rank P=0.003) and was an adverse prognostic predictor of overall survival in multivariate analysis (hazard ratio, 10.915; P=0.001). Sarcopenia was a predictor of serious in-hospital complications in multivariate analysis (odds ratio, 3.508; P=0.042). Conclusions: In patients undergoing curative resection for gastric cancer, there was a statistically significant association between sarcopenia and both decreased overall survival and serious post-operative complications. The measurement and reporting of skeletal muscle index on pre-operative computed tomography should be considered.

#Sarcopenia #Stomach neoplasms #Prognosis #Morbidity #Tomography #X-ray computed

참고문헌 (28)

참고문헌 신청

Ferlay JS / 2012 / GLOBOCAN 2012: cancer incidence, and mortality and prevalence worldwide in 2012 [Internet]

National Cancer Institute / 2017 / Surveillance, epidemiology, and end results program. Cancer stat facts: stomach cancer [Internet]

Cunningham D / 2006 / Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer / N Engl J Med 355:11~20

Bosing NM / 2000 / Gastric cancer: which patients benefit from systematic lymphadenectomy / Eur J Surg Oncol 26:498~505

Selby LV / 2015 / Morbidity after total gastrectomy: analysis of 238 patients / J Am Coll Surg 220:863~871

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