Multiple Primary Malignancies in Patients with Multiple Early Gastric Cancer

김대훈; 김수미; 최민규; 손태성; 배재문; 김성

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자료유형: 학술저널

저자정보: 김대훈 (충북대학교) 김수미 (성균관대학교) 최민규 (성균관대학교) 손태성 (성균관대학교) 배재문 (성균관대학교) 김성 (삼성서울병원)

저널정보: 대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제17권 제2호

발행연도: 2017.6

수록면: 154 - 161 (8page)

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Purpose: This study aimed to investigate the correlation between multiple early gastric cancer (MEGC) and multiple primary malignancies during the follow-up of patients with gastrectomy. Materials and Methods: The number of primary tumors detected in other organs after gastrectomy for early gastric cancer (EGC) has been increasing because of improved survival and surveillance programs. A total of 3,129 patients underwent radical gastrectomy for treatment of EGC at Samsung Medical Center from January 2000 to December 2005. Of these, 3,057 patients were selected and their medical records were retrospectively analyzed. Results: Among the 3,057 patients, 148 (4.8%) had MEGC, 84.5% were male, 57.4% were over 60 years old, 42.6% had a macroscopic type EGC IIb main lesion, and 68.9% had well-differentiated tumors with a significantly high incidence of MEGC. There were no differences between patients with solitary early gastric cancer (SEGC) and those with MEGC with regard to overall survival or recurrence-free survival, but MEGC was an independent risk factor for metachronous primary malignancies in other organs (P=0.004, hazard ratio [HR]=2.444). Conclusions: MEGC is not a risk factor for poor prognosis after curative gastrectomy, but it is a risk factor for metachronous primary malignancies in other organs during postoperative follow-up; therefore, careful surveillance is needed.

#Stomach neoplasms #Neoplasms #second primary #Neoplasms #multiple primary

참고문헌 (22)

참고문헌 신청

Peng J / 2010 / Epidemiology, pathology and clinical management of multiple gastric cancers: a mini-review / Surg Oncol 19:e110~e114

Moertel CG / 1957 / Multiple gastric cancers; review of the literature and study of 42 cases / Gastroenterology 32:1095~1103

Noh SH / 1995 / Clinical study of synchronous multiple early gastric cancer / J Korean Surg Soc 49:328~334

박성수 / 2001 / 다발성 조기위암의 임상적 고찰 / Journal of Gastric Cancer 1(3):150~154

Takeshita K / 1997 / Treatment of primary multiple early gastric cancer : from the viewpoint of clinicopathologic features / World J Surg 21:832~836

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김대훈

소속기관 충북대학교

주요연구분야 의약학 > 기초의학 > 약리학 공학 > 건축공학 > 건축공학 일반

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김수미

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