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논문 기본 정보

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학술저널
저자정보
Lim Jin Gyu (Department of Pediatrics Seoul National University Bundang Hospital Seongnam the Republic of Korea.) Lee Da Hye (Department of Pediatrics Seoul National University Children's Hospital Seoul the Republic of Korea.) Oh Kyung Jin (Department of Pediatrics Seoul Metropolitan Government-Seoul National University Boramae Medical Ce) Choi Sujin (Department of Pediatrics Seoul National University College of Medicine Seoul the Republic of Korea.) Song Young Hwan (Department of Pediatrics Seoul National University Bundang Hospital Seongnam the Republic of Korea.) Lee Joowon (Department of Pediatrics Seoul National University Bundang Hospital Seongnam the Republic of Korea.) Lee Hyunju (Department of Pediatrics Seoul National University Bundang Hospital Seongnam the Republic of Korea.)
저널정보
대한소아감염학회 Pediatric Infection and Vaccine Pediatric Infection and Vaccine 제28권 제3호
발행연도
2021.12
수록면
173 - 180 (8page)
DOI
10.14776/piv.2021.28.e17

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After initial reports of multisystem inflammatory syndrome in children (MIS-C) in April 2020 in Europe, this disease has been known to occur in children with recent history of coronavirus disease 2019 (COVID-19) and most cases have been reported in Europe and the Unites States of America. We report a case of a 14-year-old girl who was diagnosed with MIS-C with acute myocarditis and successfully treated with intravenous immunoglobulin (IVIG), methylprednisolone, and anakinra. At initial presentation, she had persistent high fever, generalized rash, generalized swelling, abdominal pain, and low blood pressure. She showed a remarkably elevated level of inflammation and cardiac enzyme markers and had a previous history of COVID-19 5 weeks before the initial presentation. After extensive work up, other infectious and non-infectious causes were excluded. She was diagnosed with MIS-C and initially treated with IVIG and high-dose methylprednisolone; however, despite treatment, her heart function deteriorated and coronary artery dilatation progressed. Therefore, anakinra, an interleukin-1 receptor antagonist, was administered on hospital day 6, after which her cardiac function exhibited improvement. She was discharged on hospital day 19 without any symptoms, and follow-up echocardiography after 1 month revealed fully recovered heart function with normal coronary arteries.
#COVID-19 #SARS-CoV-2 #Pediatric multisystem inflammatory disease #COVID-19 related #Myocarditis

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참고문헌 (20)

참고문헌 신청
Lee PI / 2020 / Are children less susceptible to COVID-19? / J Microbiol Immunol Infect 53:371~372 google schola Epidemiology Working Group for NCIP Epidemic Response / 2020 / Chinese Center for Disease Control and Prevention. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China / Zhonghua Liu Xing Bing Xue Za Zhi 41:145~151 google schola Riphagen S / 2020 / Hyperinflammatory shock in children during COVID-19 pandemic / Lancet 395:1607~1608 google schola Verdoni L / 2020 / An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study / Lancet 395:1771~1778 google schola Korea Disease Control and Prevention Agency (KDCA) / Press release: COVID-19 status in Korea (May 25th, regular briefing) google schola

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