지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 563 - 569 (7page)
- DOI
- 10.3988/jcn.2021.17.4.563
이용수
초록· 키워드
오류제보하기
Background and Purpose Acute colonic pseudo-obstruction (ACPO) is a common but understudied complication in neurocritically ill patients. The acetylcholinesterase inhibitor neostigmine can be used to treat ACPO in patients who do not respond to conventional treatment.
This study investigated the effectiveness and adverse events when using neostigmine to manage ACPO in neurocritically ill patients.
Methods This retrospective study investigated patients with ACPO who were treated using neostigmine in the neurological intensive-care units at two centers between March 2017 and August 2020. Neostigmine was administered intravenously or subcutaneously (at doses ranging from 0.25 mg to 2 mg) according to the protocols at the two centers. The outcomes were bowel movements and the changes in colon diameters on abdominal radiographs. Safety events such as bradycardia, vomiting, salivation, and sweating were evaluated.
Results This study included 31 subjects with a mean age of 46.8 years (65.4% males). All patients had a bowel movement at a median of 120 minutes after administering neostigmine.
The colon diameter decreased by a median of 17.5 mm (paired t-test: p<0.001) regardless of the dose and treatment protocols. Multilevel analysis confirmed that the mean colon diameter decreased from 66 mm pretreatment to 47.5 mm posttreatment (p<0.001), with an intraclass correlation coefficient of 13%. Three patients (9.7%) exhibited hypersalivation, sweating, bradycardia, and vomiting. Bradycardia (heart rate, 42 beats/minute) occurred in one patient (3.2%), and was successfully managed by injecting atropine.
Conclusions Neostigmine injection is a safe and effective treatment option for ACPO in neurocritically ill patients who fail to respond to conservative management.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
De Giorgio R / 2009 / Acute colonic pseudo-obstruction / Br J Surg 96:229~239
Antonucci A / 2008 / Chronic intestinal pseudo-obstruction / World J Gastroenterol 14:2953~2961
Vanek VW / 1986 / Acute pseudo-obstruction of the colon(Ogilvie’s syndrome). An analysis of 400 cases / Dis Colon Rectum 29:203~210
Ritz MA / 2000 / Impacts and patterns of disturbed gastrointestinal function in critically ill patients / Am J Gastroenterol 95:3044~3052
Kram B / 2018 / Efficacy and safety of subcutaneous neostigmine for ileus, acute colonic pseudo-obstruction, or refractory constipation / Ann Pharmacother 52:505~512
Antonucci A / 2008 / Chronic intestinal pseudo-obstruction / World J Gastroenterol 14:2953~2961
Vanek VW / 1986 / Acute pseudo-obstruction of the colon(Ogilvie’s syndrome). An analysis of 400 cases / Dis Colon Rectum 29:203~210
Ritz MA / 2000 / Impacts and patterns of disturbed gastrointestinal function in critically ill patients / Am J Gastroenterol 95:3044~3052
Kram B / 2018 / Efficacy and safety of subcutaneous neostigmine for ileus, acute colonic pseudo-obstruction, or refractory constipation / Ann Pharmacother 52:505~512
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